正大捷普联合重组人干扰素a-2b治疗疱疹性角膜炎
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摘要： 目的评价阿昔洛韦滴眼液(正大捷普)和重组人干扰素a-2b滴眼液治疗单纯疱疹性角膜炎(HSK)的临床疗效。 方法治疗组HSK 62例，69眼，滴用正大捷普和重组干扰素a-2b滴眼液，并静脉滴注阿昔洛韦，对照组HSK 41例，43眼，用普通阿昔洛韦滴眼液联合羟苄唑滴眼液并静脉滴注阿昔洛韦，比较两组的治愈率、有效率及复发率。结果治疗组疗效明显优于对照组(P<0.01)，治疗组复发率低于对照组。结论临床应用正大捷普联合重组干扰素a-2b滴眼液治疗单纯疱疹性角膜炎能提高疗效，降低复发率，具有较好的治疗和抗复发效果，降低了致盲率。
关键词：阿昔洛韦滴眼液；重组人干扰素a-2b滴眼液；角膜炎；疱疹性
中图分类号：R772.21文献标识码：A文章编号：1672-979X(2007)05-0017-03
Effect Evaluation of Aciclovir Eye Drops Combined with Recombinant Human Interferon a-2b Eye Drops in Treatment of Herpes Simplex Keratitis
CHEN Xiang-dong，TANG Luo-sheng
(Department of Ophthalmology,the Second Xiang ya Hospital of Central South University Hunan Changsha 410011 China)
Abstract：Objective To evaluate the effect of aciclovir eye drops combined with recombinant human interferon a-2b eye drops in the treatment of herpes simplex keratitis (HSK).Methods In the treatment group 69 eyes of 62 cases were treated with aciclovir eye drops combined with recombinant human interferon a-2b eye drops, at the same time, intravenous drip of aciclovir, compared with the control group 43 eyes of 41 cases which were treated with ordinary aciclovir eye drops combined with hydrobenzole hydrochloride eye drops as well as intravenous drip of acyclovir. Their cure rate, effective rate and relapse rate were compared.Results The curative effect of the treatment group was superior to that of the control group (P<0.01) and the relapse rate in 1 year later was obviously low. Conclusion Aciclovir eye drops combined with recombinant human interferon a-2b eye drops for the treatment of HSK can improve efficacy, decrease relapse and blindness.
Key words：aciclovir eye drops; recombinant human interferon a-2b eye drops; keratitis; herpes
单纯疱疹病毒性角膜炎(HSK)主要由单疱病毒I型(HSV-I)感染眼部引起，人群感染率高达90%以上，发病率及致盲率居角膜病的首位。近年，由于对药物耐药及抗体免疫功能受到干扰，HSK增多且易复发，迁延不愈，对视功能损害较大，故采取有效措施治疗HSK及预防复发十分重要。我院用正大捷普联合重组人干扰素a-2b滴眼液取得了较好的疗效，现报告如下。
1资料与方法
1.1一般资料
本组单纯疱疹病毒性角膜炎103例112眼，其中男61例，女42例，年龄15～65岁。平均41.52±15.65岁，病程最短3 d，最长5个月，最多复发5次。随机将103例分为2组，观察组62例、69眼，其中树枝状角膜炎19例、22眼；地图状角膜炎25例、28眼；盘状角膜炎16例、17眼；基质坏死型2例、2眼；平均年龄40.72±14.75岁。对照组41例、43眼，其中树枝状角膜炎13例14眼；地图状角膜炎16例、17眼；盘状角膜炎10例、10眼；基质坏死型角膜炎2例、2眼；平均年龄40 ......
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