铝螯合剂DFP对荷铝大鼠脾脏及附睾中铝和必需元素的影响
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摘要：目的探讨铝螯合剂1,2-二甲基-3-羟基-4-吡啶酮(1,2-dimethyl-3-hydroxy-4-pyridone，DFP)对荷铝大鼠脾脏及附睾中铝的促排作用及组织中锌、铜、铁、钙、镁等必需元素的影响。方法随机将30只雄性Wistar大鼠分为6组：阴性对照组、铝染毒组、预防组及低、中、高剂量组，AlCl3染毒3周后分别给予不同剂量的DFP 1周，测定脾脏及附睾中铝、锌、铜、铁、钙、镁等元素的含量。结果铝染毒组大鼠脾脏、附睾中的铝含量均显著高于阴性对照组，预防组、低、中、高剂量组显著低于铝染毒组，且高剂量组与阴性对照组的差异无统计学意义；铝染毒组大鼠脾脏铜含量显著低于阴性对照组，中、高剂量组显著高于铝染毒组，且与阴性对照组的差异无统计学意义；各组大鼠脾脏中锌、铁、钙、镁含量的差异均无统计学意义；铝染毒组大鼠附睾中的锌含量显著低于阴性对照组，预防组、低、中、高剂量组显著高于铝染毒组，高剂量组与阴性对照组的差异无统计学意义；各组大鼠附睾中铜、铁、钙、镁含量的差异均无统计学意义。结论铝摄入量过多可使铝在脾脏及附睾中蓄积，DFP可促进铝的排出，且对锌、铜、铁、钙、镁等元素在体内的平衡不产生影响。
关键词：铝；螯合剂；必需元素
中图分类号：R115文献标识码：A文章编号：1672-979X(2007)11-0024-04
Effect of Deferiprone on Contents of Aluminum and Essential Elements in Spleen and Epididymis in Aluminum-Induced Rats
ZHUO Jin-hua, LIU Ping, LI Hong-yan, ZHAO Hui-juan
(Department of Chemistry and Microbacteria Detection, College of Public Health, Shandong University, Jinan 250012, China)
Abstract：Objective To investigate the effect of 1,2-dimethyl-3-hydroxy-4-pyridone(deferiprone, DFP) on the contents of aluminum(Al), zinc(Zn), copper(Cu), iron(Fe), calcium(Ca) and magnesium(Mg) in spleen and epididymis in aluminum-induced rats. Methods Thirty male wister rats were randomly divided into 6 groups of negative control group, aluminum-induced group, prevention group, low, moderate and high DFP doses groups. The rats were administered with aluminum chloride for 3 weeks, then, they were treated with different doses of DFP for 1 week. The contents of Al, Zn, Cu, Fe, Ca and Mg in spleen and epididymis were measured. Results The aluminum concentrations in spleen and epididymis of aluminum-induced group were remarkably higer than negative control group, and that of prevention group and three different dose groups were significantly lower thanaluminum-induced group ......
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