摘要：禽流感病毒(avian influenza virus，AIV)是引起鸟禽类烈性传染病的病毒。1997年发现AIV跨越物种障碍使人感染。H5N1是有强致病力的禽流感病毒，感染H5N1的患者死亡率高。本文综述了禽流感病毒致病机制研究以及抗H5N1禽流感病毒新药的进展，包括：神经氨酸苷酶新抑制剂及核酸基的抗禽流感病毒新药——免疫调节双链核糖核酸聚ICLC脂质体和反义寡核苷酸。

    关键词：H5N1禽流感病毒；致病机制；抗禽流感病毒新药；聚ICLC脂质体；反义寡核苷酸

    中图分类号：R978.7文献标识码：A文章编号：1672-979X(2008)09-0058-04

    Progress on H5N1 Avian Influenza Virus and New Antiviral Drugs

    CHEN Zhi-zhong

    (School of Pharmacy, Fudan University, Shanghai 200032, China)

    Abstract ：The avian influenza virus (AIV) is a strong virus infection in birds. In1997, it was found that AIV could infect human beings over the species barrier. H5N1 is a virus with strong pathogenicity, so the people infected by H5N1 show a high death rate. In this article, the progress on pathogenic mechanism of AIV and new anti-H5N1 drugs is reviewed, including a new neuraminidase inhibitor and a nucleic acid-based anti-avian influenza virus drug—immunomodulating liposome-encapsulated dsRNA poly ICLC and antisense oligonucleotides. ......