摘要：RNA干扰(RNAi)是控制正常基因表达的一种机制，近来作为一种潜在的技术用于肿瘤、传染病和代谢性疾病的治疗。本文仅就RNA干扰的发现、作用机制以及在肿瘤治疗中的应用和所面临的问题做一简要介绍。

    关键词：RNA干扰；小干扰RNA；基因沉默；肿瘤

    中图分类号：Q522文献标识码：A文章编号：1672-979X(2009)01-0054-04

    RNA Interference and Tumor Gene Therapy

    JU Ji-yu, LI Zai-lian

    (Department of Immunology, Weifang Medical University; Key Laboratory of Immunology in Universities of Shandong, Weifang 261042, China)

    Abstract：RNA interference is a mechanism for controlling normal gene expression, which has been employed as a potential technology for a wide range of disorders such as tumors, infectious diseases and metabolic disorders. This paper reviews the discovery, mechanism of RNA interference and its application in tumor diagnosis and prevention, as well as some challenges.

    Key words：RNA interference; small interfering RNA; gene silencing; tumor

    基因治疗是一种特异性的治疗方法 ......