三苯氧胺对乳腺癌患者宫颈的影响(1)
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[摘要] 目的：探讨三苯氧胺(TAM)对乳腺癌患者宫颈细胞形态学的影响。方法：选取233例乳腺癌术后服用TAM患者(TAM组)及106例无TAM服药史的乳腺癌术后患者(对照组)，所有患者均行宫颈检查，ThinPrep液基薄层制片，观察其细胞形态学改变。结果：TAM组宫颈上皮细胞异常的发生率为11.6%(27/233)，明显高于对照组4.7%(5/106)(P0.05)。TAM组绝经前后宫颈上皮细胞异常及霉菌感染的发生率分别为15.4%、8.5%、5.8%和3.9%，均无显著差异。结论：乳腺癌患者服用TAM后宫颈上皮细胞异常的发生率增高，与绝经状态无关。对乳腺癌术后服用三苯氧胺患者应进行规律的宫颈涂片检查。
[关键词] 三苯氧胺；乳腺癌；ThinPrep；宫颈上皮细胞异常
[中图分类号] R737.9[文献标识码]C [文章编号]1673-7210(2008)08(a)-070-03
The effects of tamoxifen on cervix of the breast cancer patients
LI Xiang-ju, WANG Ping, LI Xiang-hong，LI Ji-you, LU Ai-ping
(Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital&Institute, Beijing100036, China)
[Abstract] Objective: To investigate the cytological changes of cervical smears of the breast cancer patients receiving tamoxifen (TAM).Methods: Cervical smears from 233 postoperate breast cancer patients treated with TAM (the TAM group) and 106 smears from breast cancer patients without TAM treatment (the control group) were evaluated. All the smears were prepared by ThinPrep 2 000 and diagnosed according to the Bethesda System(TBS).Results: The incidence of cervical epithelial abnormalities of the TAM group was 11.6%(27/233), higher than that of the control group 4.7%(5/106) (P
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