低分子肝素钠联合银杏达莫治疗进展性缺血性脑卒中疗效观察(1)
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[摘要] 目的：观察低分子肝素联合银杏达莫治疗进展性缺血性脑卒中的疗效。方法：选择135例发病在12～48 h，病情呈进行性加重的进展性缺血性脑卒中患者，随机分为3组，分别接受低分子肝素治疗、银杏达莫治疗、低分子肝素和银杏达莫联合治疗。1个疗程后作疗效判定，并监测治疗前后血液流变学的变化。结果：1个疗程后低分子肝素组总有效率为80.0%、联合用药组总有效率为88.9%，明显高于银杏达莫组的71.1%，而且治疗前后血流变学的变化亦有显著性的差异，特别以联合用药组的总有效率最高和血流变学变化最明显，同时未发现出血倾向等不良反应。结论：低分子肝素能有效地治疗进展性缺血性脑卒中，与银杏达莫联合使用具有协同作用，临床疗效确切、安全。
[关键词] 低分子肝素；银杏达莫；进展性缺血性脑卒中；联合
[中图分类号] R743[文献标识码]C [文章编号]1673-7210(2008)11(b)-027-02
The observation of curative effect of low molecular weight heparin combined with Ginkgo bilobate extract in treating progressive ischemic stroke
HUANG Dan-dan, DENG Yao-fang, WU Yong, QIU Guan-yang, CUI Ming-zhi
(People's Hospital of Gaozhou, Guangdong Province, Guangzhou525200, China)
[Abstract] Objective: To observe the curative effect of low molecular weight heparin combine with Ginkgo bilobate extract in treating progressive ischemic stroke. Methods: We selected 135 cases of Progressive ischemic stroke happened from 12 hours to 48 hours, and divided into three groups randomly, who received the low molecular weight heparin, Ginkgo bilobate extract and low molecular weight heparin combined with Ginkgo bilobate extract, respectively. After one course of treatment to efficacy and monitoring of blood rheology before and after treatment were determined. Results: After one course of treatment, total effective rate of low molecular weight heparin and low molecular weight heparin combine with Ginkgo bilobate extract were 80.0% and 88.9% separately，much higher than total effective rate of Ginkgo bilobate extract 71.1%. The change of the blood rheology in pretherapy and post-treatmen had statistical significance. In the group of treating with low molecular weight heparin combine with Ginkgo bilobate extract had the higher total effective rate and much evident change than the other groups, at the same time no bleeding tendency and other adverse reactions were found. Conclusion: Low molecular weight heparin are effective in treatment of progressive ischemic stroke, while low molecular weight heparin combine with Ginkgo bilobate extract has the synergistic effect, and clinical effect is available and safe ......
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