两种方法治疗胃溃疡的临床研究
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[摘要] 目的：观察两种方法治疗胃溃疡对其血清胃泌素及胃黏膜血管内皮生长因子水平的影响。方法：经胃镜和活检证实的活动性胃溃疡患者80例，随机分为中西医结合组(治疗组)40例和西医组(对照组)40例，观察两组患者治疗前后胃泌素、胃黏膜血管内皮生长因子水平的变化。结果：治疗组治疗后胃泌素为(30.2±9.9) pmol/L，明显低于治疗前的(36.0±11.2) pmol/L(t=2.345，P<0.05)；血管内皮生长因子为(16.2±5.6)%，明显高于治疗前的(6.2±2.3)% (t=2.415，P<0.05)；对照组治疗后胃泌素为(29.3±8.9) pmol/L，明显低于治疗前的(35.8±10.8) pmol/L(t=2.245，P<0.05)；血管内皮生长因子为(13.8±4.3)%，明显高于治疗前的(6.6±2.4)%(t=2.325，P<0.05)；治疗组治愈率为90.0%，明显高于对照组的65.0%(χ2=3.98，P<0.05)。结论：中西医结合可以提高溃疡愈合质量，可能与血胃泌素水平、血管内皮生长因子表达有关。
[关键词] 胃溃疡；胃泌素；血管内皮生长因子
[中图分类号] R573.1[文献标识码]A [文章编号]1673-7210(2009)02(b)-021-02
The clinical study in patients with gastric ulcer by two treatment methods
HUANG Xing-ai1, ZHANG Yuan-fang1, GU Li-hua1, ZHAO Wen-li2
(1.Department of Internal Medicine, Xingxu Hospital, Huiyang City, Huiyang516200, China; 2. Pathology Department, Huizhou Central Hospital, Huizhou516001, China)
[Abstract] Objective: To observe the levels of blood gastrin and vascular endothelial growth factor(VEGF) in patients with gastric ulcer. Methods: 80 cases with gastric ulcer were divided into Chinese and Western medicine group(treatment group) and Western medicine group (control group),each group had 40 cases. Observed the levels of gastrin and VEGF before and after treatment. Results: In treatment group, the level of gastrin was (30.2±9.9) pmol/L after treatment, which was significantly lower than (36.0±11.2) pmol/L before treatment(t=2.345，P<0.05); the level of VEGF was (16.2±5.6)%,which was significantly higher than (6.2±2.3)% before treatment(t=2.415,P<0.05).In control group,the level of gastrin after treatment was (29.3±8.9) pmol/L,which was significantly lower than (35.8±10.8) pmol/L before treatment(t=2.245，P<0.05); the level of VEGF was (13.8±4.3)%, which was significantly higher than (6.6±2.4)% (t=2.325,P<0.05) before treatment.The cure rate was 90.0% in treatment group,which was significantly higher than 65.0% in control group (χ2=3.98,P<0.05). Conclusion: Chinese and Western medicine can improve the quality of ulcer healing, which is related with serum gastrin, VEGF levels ......
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