应用斯帕丰治疗先兆流产的疗效观察及护理
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[摘要] 目的：观察斯帕丰治疗先兆流产的临床疗效并探讨护理注意事项。方法：将243例先兆流产孕妇分为两组，A组(123例)采用口服斯帕丰治疗；B组(120例)肌注黄体酮治疗。比较两组患者临床疗效，并比较A组中继续妊娠患者与同期正常妊娠患者(100例无妊娠早期出血孕产妇)妊娠结局之差异。结果：服用斯帕丰治疗组(A组)有效率为86.2%,肌注黄体酮治疗组(B组)为85.0%,两组间疗效比较，无显著性差异(P>0.05)；服用斯帕丰治疗组和正常妊娠组相比较，服用斯帕丰治疗组胎盘粘连和便秘发生率高于正常妊娠组(P<0.05)，其余各项并发征两组相比较，无显著性差异(P>0.05)。结论：斯帕丰可以作为一种有效的、对妊娠结局无明显不良影响的治疗先兆流产的新方法。
[关键词] 先兆流产；治疗；妊娠结局；斯帕丰
[中图分类号] R714.21[文献标识码]C [文章编号]1673-7210(2009)02(b)-096-02
Effect of Spasfon on treatment of threatened abortion patients and nursing notation
ZHAO Xiang-zhi, LIU Xu-dong, YIN Bao-min
(Zhuhai Maternity and Child Care Hospital, Zhuhai519000, China)
[Abstract] Objective: To study the effect of Spasfon in treatment of threatened abortion patients and nursing notation. Methods: Two hundreds and forty three cases of threatened abortion patients were divided into Spasfon oral group(n=123) and intramuscular Injection group(n=120) who were treated with Progesterone muscular injection. The effectiveness of the two groupswere compared and the complications of the Spasfon oral group were compared with normal pregnancy group. Results: The effectiveness of Spasfon oral group was 86.2% and the effectiveness of progesterone muscular injection group was 85.0%, there was no significant difference between the two groups(P>0.05).The complications of placental adherence and constipation occurred higher in Spasfon oral group than in Progesterone muscular injection group(P<0.05),and there was no significant difference between the two groups in other complications of pregnancy(P>0.05). Conclusion: Spasfonact as a new method in treatment of threatened abortion patients effectively with little adverse effect on pregnancy outcome.
[Key words] Threatened abortion; Treatment; Pregnancy outcome; Spasfon
先兆流产是妊娠早期常见的一种常见疾病，以往多采用大量长时间应用孕激素、绒毛膜促性腺激素的方法保胎治疗。但是近年来许多学者提出黄体酮及其衍生物大剂量保胎有致畸作用。现在欧洲已不提倡用于治疗先兆流产，为了更有效、安全地治疗先兆流产，笔者采用斯帕丰治疗先兆流产。我院2004年1月～2005年12月共收住先兆流产保胎并延长孕周至足月分娩孕妇243例，其中应用斯帕丰治疗先兆流产123例，疗效良好。现对应用斯帕丰治疗先兆流产疗效进行对比分析，并与同期正常分娩100例孕妇进行妊娠结局尤其分娩后新生儿情况、孕期并发症进行临床观察比较，现将结果报道如下：
1资料与方法
1.1一般资料
选取2004年1月～2005年12月本院因先兆流产保胎并延长孕周至足月分娩孕妇共243例作为研究对象。先兆流产的诊断标准为：在停经28周前有阴道出血，伴或不伴腰酸、腹痛症状；窥器检查证实出血来自宫腔；B超检查提示宫内胚胎存活。部分停经时间较早仅见孕囊未见心管搏动的患者7～10 d复查B超证实胚胎存活 ......
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