急性中枢神经系统感染患儿IL-6和TNF-α的变化及临床意义(1)
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[摘要] 目的：研究急性中枢神经系统感染患儿血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的变化及临床意义。方法：采用ELISA法对53例初诊为中枢神经系统感染患儿，其中，化脓性脑膜炎(PM)22例，病毒性脑膜脑炎(VE)31例，进行了血清IL-6和TNF-α水平测定，并与60例正常儿童的测定值进行比较。结果：PM组患儿血清中IL-6和TNF-α水平分别为(636±329) pg/ml和(485±261) pg/ml，明显高于VE组的(175±136) pg/ml和(63±52) pg/ml和对照组的(12±8) pg/ml和(17±13) pg/ml(均P<0.001)，VE组血清中IL-6和TNF-α水平亦明显高于对照组(P<0.01和P<0.05)。结论：IL-6和TNF-α参与了急性中枢神经系统感染的病理生理过程，血清中IL-6和TNF-α的测定可能对急性中枢神经系统感染的诊断具有一定的意义。
[关键词] 脑膜炎；血清；白细胞介素-6；肿瘤坏死因子
[中图分类号] R512.3[文献标识码]A [文章编号]1673-7210(2009)03(c)-030-02
The change and clinical significance of IL-6 and TNF-α in children patients with acute central nervous system infection
PAN Xuefeng1, ZHENG Dingrong2, LIU Zhiwei2
(1.Department of Pediatrics, the Huizhou Center People's Hospital, Huizhou516001, China; 2.Xixiang People's Hospital of Bao'an District, Shenzhen City, Shenzhen518102, China)
[Abstract] Objective: To study the change and clinical significance of interleukin-6 (IL-6) and tumor necrosis factor-Alpha (TNF-α) in children patients with acute central nervous system infection. Methods: ELISA was employed to detect the level of IL-6 and TNF-α in 53 children patients preliminarily diagnosed as acute central nervous system infection, and 22 patients were purulent meningitis (PM), 31 patients were viral meningitis (VE) within them. Results: The levels of IL-6 and TNF-α in blood serum of PM group were (636±329) pg/ml and (485±261) pg/ml respectively, significantly higher than that in VE group [(175±136) pg/ml and (63±52) pg/ml respectively] and control group [(12±8) pg/ml and (17±13) pg/ml respectively] (average P<0.001). The levels of IL-6 and TNF-α in blood serum of VE group were also obviously higher than that in control group(P<0.01 and P<0.05). Conclusion: IL-6 and TNF-α participate in the pathology physiological process of acute central nervous system infection, the detection of the levels of IL-6 and TNF-α in blood serum probably plays a role in diagnosing acute central nervous system infection.
[Key words] Meningitis; Serum; IL-6; Tumor necrosis factor ......
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