阿托伐他汀对兔心肌缺血再灌注损伤的实验研究(1)
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[摘要] 目的：研究阿托伐他汀(ATV)对心肌缺血再灌注损伤的影响及两种ATP依赖的K+(K+-ATP)通道的作用。方法：将健康家兔随机分为对照组、ATV组、ATV+5-HD(A1组)、ATV+HMR1883(A2组)。进行30 min局部缺血和30 min再灌注。实验中持续监测左室舒张末期压(LVEDP)、左心室压最大变化速率(±dp/dtmax)的变化，再灌注结束后用伊文蓝和TTC染色法确定缺血和梗死心肌范围。结果：与对照组相比，ATV组及A2组的梗死面积显著减少(P<0.05)，各项心功能指标在再灌注30 min后明显改善(P<0.05)；这种效应能够被5-HD所消除，A1组与对照组相比无显著性差异(P>0.05)。结论：ATV对心肌缺血再灌注损伤有早期保护效应，且这种作用可能与心肌线粒体KATP通道有关系。
[关键词] 阿托伐他汀；心肌缺血再灌注损伤；ATP敏感性钾通道；保护效应
[中图分类号]R961 [文献标识码] A[文章编号] 1673-7210(2009)06(b)-043-02
The effects of atorvastatin on the prevention of heart muscle ischemia-reperfusion injury in rabbits
ZHOU Changqing, MA Jie
(Department of Candiothoracic Surgery, the Second Teaching Hospital of Shanxi Medical University, Taiyuan 030001, China)
[Abstract] Objective: To observe the effect of atorvastatin(ATV) on myocardial ischemia-reperfusion injury and the role of two ATP-sensitive K+ channels. Methods: Thirty-two rabbits were randomly divided into four groups, control group, ATV group, ATV+5-HD(A1) group, ATV+HMR1883(A2) group. All rabbits were subjected to 30 min ischemia and 30 min reperfusion. The max rate of rise of left ventricular pressure(±dp/dtmax) and left ventricular end-diastolic pressure(LVEDP) were detected during the experiment. At the end of reperfusion, the area of necrosis and area of ischemia were determined by Evans blue and TTC staining. Results: Compared with the control group, the indexes of heart function were improved significantly and infarct size(AN/AAR) were reduced(P<0.05) in ATV group and A2 group. And this effect was blocked by 5-HD. There was no statistically significant between the control group and A1 group(P>0.05). Conclusion: Atorvastatin exerts an early cardio protective effect against myocardial ischemia reperfusion in rabbits and mitochondrial KATP channel is likely involved in this protective mechanism.
[Key words] Atorvastatin; Myocardial ischemia-reperfusion; ATP-sensitive K+ channels; Protective effect
随着医疗技术的发展，各种治疗缺血性心脏病的方法逐渐开展(如PTCA、CABG)，在人们欣喜于闭塞冠脉能够再通的同时，也发现当冠脉血流恢复后极易发生再灌注损伤(I/R)。近年来大量临床观察[1-2]发现，他汀类药物除降脂作用外还有许多非降脂作用，其中包括抗I/R的保护效应，但是具体机制尚未明确，相关研究已经成为热点问题。本试验的目的在于检测ATV对健康家兔在体心脏I/R的作用及机制 ......
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