纳米银杏对动脉粥样硬化早期大鼠主动脉壁ICAM-1基因表达的影响
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[摘要] 目的:观察纳米银杏(银杏黄酮-磷脂复合物)对动脉粥样硬化(AS)早期大鼠主动脉壁细胞间黏附分子-1(ICAM-1) mRNA及其蛋白表达水平的影响。方法:采用生化分析、免疫组化、实时定量荧光RT-PCR以及凝胶电泳,观察纳米银杏对大鼠主动脉ICAM-1 mRNA及其蛋白表达水平的影响。结果:与模型组比较,纳米银杏组ICAM-1表达明显降低(P<0.01);与银杏黄酮组比较,纳米银杏组ICAM-1表达明显降低(P<0.01)。结论:银杏黄酮及纳米银杏可下调AS早期大鼠主动脉壁ICAM-1的高表达,纳米银杏的作用明显优于银杏黄酮。
[关键词] 纳米银杏;大鼠;动脉粥样硬化;黏附分子
[中图分类号] R-332[文献标识码]A [文章编号]1673-7210(2009)07(b)-009-02
The effects of the compounds of Ginkgo Flavone Phospholipid on the expression of intercellular adhension molecule-1 in rat aorta at the early stage of atherosclerosis
XIAO Hailong
(Department of Clinical Medicine, Weifang Medical University, Weifang 261042, China)
[Abstract] Objective: To observe the effects of the compounds of Ginkgo Flavone Phospholipid (FGP) on the expression of intercellular adhension molecule-1 (ICAM-1) mRNA and protein in rats aorta at the early stage of atherosclerosis (AS) ......
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