地诺前列酮在足月孕妇引产中的临床对比观察(1)
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[摘要] 目的:评价普贝生(地诺前列酮)对足月孕妇引产的效果和安全性。方法:采用普贝生与缩宫素临床对比,普贝生治疗90例,缩宫素治疗60例,观察其对150例足月宫颈低评分孕妇促宫颈成熟的有效性和对产程的影响。结果:普贝生能提高宫颈Bishop评分(2.76±1.01)分,促宫颈成熟效果达88.89%,临产时间为(19.8±10.1) h,总产程(6.8±3.1) h,剖宫产率降至16.67%,与缩宫素比较,差异有明显的统计学意义。普贝生和缩宫素临床使用均无严重不良反应。结论:普贝生(地诺前列酮)是一种有效的促宫颈成熟和引产药物,使用方便,安全可靠。
[关键词] 普贝生(地诺前列酮);阴道栓剂;促宫颈成熟;引产
[中图分类号] R719.3+1[文献标识码]A [文章编号]1673-7210(2009)07(c)-077-02
The clinical comparison and observation of Dinoprostone to induce labor in term pregnancies
LUO Yuqing1, HUANG Sudan2, LI Wenjiao3
(1.Department of Gynecology and Obstetrics, Shenzhen 4th People's Hospital (Futian District Hospital), Shenzhen 518033, China; 2. Shenzhen 6th People's Hospital, Shenzhen 518052, China; 3.Changning Children and Maternal Hospital of Shanghai, Shanghai 200051, China)
[Abstract] Objective: To evaluate the efficiency and security of Propess (Dinoprostone) to induce labor in term pregnancies. Methods: We adopted the function of Oxytocin and Propess comparatively, 90 cases of Propess and 60 cases of Oxytocin were studied. Their efficiency to promote the ripeness of cervix and the influence on the birth process for the 150 cases of low cervical scale of term pregnancies. Results: Propess could raise the Bishop cervical scale by (2.76±1.01) scores, the efficiency to promote the ripeness of cervix could reach 88.89%, the parturient time was (19.8±10.1) hours, the total labor stages were (6.8±3.1) hours, the rate of cesarean operation dropped to 16.67%. The deviance with Oxytocin had obvious statistical significance. The clinical usage of Propess and Oxytocin had no serious adverse reactions. Conclusion: Propess (Dinoprostone) is an effective drug to promote the ripeness of cervix and induce labor. It is convenient, safe and reliable.
[Key words] Propess (Dinoprostone); Vaginal suppository; Promotion of the ripeness of cervix; Induce labor
地诺前列酮(普贝生)缓释栓是一种较为理想的足月妊娠引产药物。我院应用普贝生(Propess)对宫颈低评分产妇观察其促宫颈成熟(cervical ripening)的有效性及对产程(the course of labour)的影响。
1 资料与方法
1.1 一般资料
选取2007年6月～2008年6月我院产科入院待产的初产妇150例,入选条件:年龄23～35岁,孕38～42周,单胎头位、胎膜未破,宫颈评分≤6分,无阴道分娩及无前列腺素应用禁忌等,随机分为两组,研究组90例,对照组60例,两组孕妇年龄、孕周、宫颈评分及引产指征等无统计学差异 ......
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