传统治疗加葛根素联合辛伐他汀在治疗不稳定型心绞痛中的应用(1)
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[摘要] 目的:探讨传统治疗加葛根素联合辛伐他汀治疗不稳定型心绞痛的临床疗效。方法:选取2005年7月～2008年8月本院的58例不稳定型心绞痛患者,随机分为治疗组29例,对照组29例,两组均应用硝酸酯类,β-受体阻滞剂及阿司匹林等传统治疗,治疗组在此基础上应用葛根素联合辛伐他汀治疗,观察14 d。观察治疗前后心绞痛的发作频率,疼痛持续时间,血脂及C-反应蛋白的变化。结果:治疗14 d末治疗组心绞痛发作频率、持续时间、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及C-反应蛋白较治疗前均有显著降低,两组比较有显著性差异(P<0.05)。结论:传统治疗加葛根素联合辛伐他汀治疗不稳定型心绞痛疗效明显,是一种很好的治疗不稳定型心绞痛的方法。
[关键词] 不稳定型心绞痛;葛根素;辛伐他汀
[中图分类号] R972+.3[文献标识码]A [文章编号]1673-7210(2009)08(c)-048-02
The application of traditional treatment with Puerarin combined Simvastatin in the treatment of unstable angina
LIN Hai1, YANG Lüshun2, ZHENG Dingrong2
(1.The Second Physician Area, People's Hospital of Chaoyang District of Shantou, Shantou 515100, China; 2. Department of Laboratory, Xixiang People's Hospital, Bao'an District of Shenzhen, Shenzhen 518102, China)
[Abstract] Objective: To investigate the clinical effect of traditional treatment with Puerarin combined Simvastatin in the treatment of unstable angina. Methods: Selected 58 cases of unstable angina from July 2005 to August 2008 in our hospital, then randomly divided into the treatment group (n=29) and the control group (n=29). The two groups were treated with nitric acid lipid, Aspirin, beta blockers and traditional treatment, etc. The treatment group received traditional treatment with Puerarin combined Simvastatin, observed 14 days. Observed before and after treatment, the changes of angina attack frequency, pain duration, blood lipid and C-reactive protein. Results: Treatment for 14 days, the angina attack frequency, pain duration, TC, LDL-C, C-reactive protein of the treatment group were significantly reduced, there were significant differences in the two groups (P<0.05). Conclusion: The traditional treatment with Puerarin combined Simvastatin has a significant curative effect in patients with unstable angina, it is a kind of very good treatment of unstable angina.
[Key words] Unstable angina; Puerarin; Simvastatin
不稳定型心绞痛(UA)是介于稳定型心绞痛和急性心肌梗死与猝死之间的一组复杂的临床综合征。不稳定型心绞痛主要危险在于冠脉内不稳定的粥样斑块出现继发病理改变,使局部心肌血流量明显下降,导致心肌梗死、心性猝死。临床研究显示,早期干预治疗可明显降低UA患者死亡、心肌梗死或难治性心力衰竭的发生率 ......
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