盐酸头孢吡肟合成路线图解
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[摘要] 本文综述了第四代注射用头孢菌素盐酸头孢吡肟的合成路线,主要是以3-氯代甲基头孢菌素或7-氨基-3-乙酰甲氧基-头孢-3-烯-4-羧酸(7-ACA)为起始原料有2条合成路线,两种方法各有优势,在生产中可根据实际情况来选择适合的路线。
[关键词] 盐酸头孢吡肟;合成路线;图解
[中图分类号] R978.1[文献标识码]A [文章编号]1673-7210(2010)01(b)-017-02
Graphical synthetic routes of cefepime hydrochloride
WANG Zhixian, ZHANG Haibo, CHEN Yande
(Taizhou New Medicine Research Institution, Yangtze River Pharmaceutical Group, Taizhou 225321, China)
[Abstract] Graphical synthetic routes of the fourth generation injectable cephalosporin cefepime hydrochloride are reviewed in this article,mainly based on 3-chloro-methyl cephalosporins, or 7-amino-3-acetyl-methoxy-cephalosporin-3-en-4-carboxylic acid (7-ACA) as the starting material with two synthetic routes, both methods have advantages in the production of the actual situation can select the appropriate line ......
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