Synthesis of unsaturated fatty acid derivatives of 4-aminosalicylic ac(1)
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[Abstract] Objective: To explore the better prodrug of 4-aminosalicylic acid with higher activity and less side effects against the inflammatory bowel disease. Methods: First of all, methods to 4-ASA for the raw materials followed by formic acid with benzyl chloride and acetic anhydride, respectively, amino and hydroxyl protection. Hydride reduction and then taked off on the amino-protective group, Synthesis of new compounds by IR, MS, 1H-NMR, 13C-NMR confirmed. Results: Synthesis of three amide compounds about unsaturated fatty acid of 4-aminosalicylic acid ......
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