检测肝硬化患者血清CA125和总胆汁酸水平的临床意义(1)
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[摘要] 目的:探讨肝硬化患者血清CA125与总胆汁酸水平变化及其临床意义。方法:选择79例肝硬化患者作为实验组,根据Child-Pugh肝功能分级积分法分级;22例健康体检人员作为对照组。检测两组血清CA125与总胆汁酸水平,分析两者与肝功能分级的关系。结果:肝硬化患者血清CA125及总胆汁酸水平与对照组比较,差异有高度统计学意义(P<0.01),两者水平随肝功能损害程度的加重呈进行性升高。结论:血清CA125与总胆汁酸呈正相关,联合检测血清CA125、总胆汁酸水平能较早地反映肝脏合成及其代谢功能,对疾病的治疗和预后有重要的临床价值。
[关键词] 肝硬化;CA125;总胆汁酸
[中图分类号] R657.3+1[文献标识码]A [文章编号]1673-7210(2010)05(a)-031-02
Clinical significance of determination of serum CA125 and TBA in patients with cirrhosis
DING Yaojing
(Xili People's Hospital of Nanshan District, Shenzhen City, Shenzhen 518055, China)
[Abstract] Objective: To investigate the clinical significance of serum CA125 and TBA in patients with cirrhosis. Methods: 79 cases of patients with cirrhosis were selected as experimental group and divided according to Child-Pugh hepatic function classification. 22 healthy people were selected as normal controls. Serum CA125 and TBA were measured by automatic biochemistry analyzer. The alteration of CA125 and TBA with hepatic functional classification was investigated. Results: The levels of serum CA125 and TBA of experimental group were markedly higher than those of control group (P<0.01). The levels of serum CA125 and TBA rose gradually with the degree of hepatic functional lesion. Conclusion: Serum CA125 and TBA are positively correlated, they can reflect hepatic synthesis metabolism, evaluate clinical value of treatment and prognosis in patients with cirrhosis.
[Key words] Cirrhosis; Carbohydrate antigen 125 (CA125); Total bile acid (TBA)
血清总胆汁酸(TBA)对肝硬化、肝功能衰竭有独特的诊断价值,而血清CA125为妇科卵巢肿瘤的非特异性肿瘤标志物,发现在许多肝硬化患者血清中CA125水平也升高。本文就肝硬化患者血清CA125与TBA的关系及其临床意义作初步探讨。
1 资料与方法
1.1 一般资料
实验组79例均为我院2002年1月～2009年12月肝硬化住院患者,男性57例,女性22例,平均年龄45岁。按Child-Pugh改良分级法分级[1],根据胆红素、清蛋白、凝血指标、腹腔积液、肝性脑病进行评分,分为A、B、C三级,A级为5～6分,肝功能损害较小;B级为7～9分,肝功能损害中等;C级为10～15分,肝功能损害大。其中,A级27例,B级35例,C级17例。
对照组22例健康体检人员中,男性16例,女性6例,平均年龄42岁。
1.2 方法
两组受试人员均清晨空腹抽血,血清CA125用德国产贝克曼Acess-2型化学发光仪检测;总胆汁酸采用德国产贝克曼LX-20型全自动生化分析仪检测。
1.3 统计学处理
数据以均数±标准差(x±s)表示,采用SPSS 12.0分析,组间比较用t检验,两者相关比较用直线相关分析,P<0.05表示差异有统计学意义。
2 结果
2.1两组受试者血清CA125、TBA水平比较
见表1。
表1两组受试者血清CA125及TBA水平(x±s)
Tab.1Levels of serum CA125 and TBA of two groups (x±s)
2.2 肝硬化患者血清CA125、TBA变化
肝硬化组血清CA125、TBA水平分别为(92.5±38.8) U/ml及(26.56±17.12) μmol/L,显著高于正常对照组的(17.8±8.7) U/ml和(6.1±3.6) μmol/L,两组比较,差异有高度统计学意义(P<0 ......
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