[摘要] 通过文献检索，综述了伊立替康治疗晚期大肠癌的使用背景、药物动力学和分子生物学研究进展、临床应用及疗效以及该药的毒副反应。伊立替康作为一线抗癌药物，对晚期转移性大肠癌的治疗发挥了很好的作用，其临床治疗效果较好，毒副作用较少，患者有较好的耐受性。

    [关键词] 伊立替康；大肠癌；研究进展

    [中图分类号] R735.3+7[文献标识码]A [文章编号]1673-7210(2010)10(a)-011-03

    The advanced of clinical research for Irinotecan treatment advanced colorectal cancer

    SHIKai

    (The People′s Hospital of Jingzhou City, Hu'nan Province, Jingzhou 418400,China)

    [Abstract] Through literature search, to summarize the Irinotecan for the use background for treatment of the advanced colorectal cancer, pharmacokinetics, and progress in molecular biology research, clinical application and efficacy and toxicity of the drug. Irinotecan as anti-cancer drugs of first-line, playing a good role in treatment for advanced colorectal cancer, having a good clinical outcomes, fewer side effects and better patient tolerance.

    [Key words] Irinotecan; Colorectal cancer; Research; Advanced

    伊立替康是一种拓扑异构酶Ⅰ(Topo I)抑制剂 ......