双嘧达莫与阿魏酸钠联合应用治疗糖尿病肾病临床观察(1)
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[摘要] 目的：观察双嘧达莫与阿魏酸钠联合应用治疗糖尿病肾病(DN)患者尿白蛋白排泄率(UAER)、血肌酐(SCr)、尿素氮(BUN)、尿内皮素(ET-1)水平的变化。方法：60例DN 患者在糖尿病常规治疗、皮下注射胰岛素等基础上，加用双嘧达莫(30 mg/d)和阿魏酸钠(300 mg/d)，分别加入生理盐水200 ml中静滴，治疗4周。结果：经治疗后，患者UAER、SCr、BUN、ET-1均较治疗前显著下降(均P<0.01)。结论：双嘧达莫能抑制血小板功能，还具有扩张血管、增加肾脏血流量、减少蛋白尿、保护肾脏的作用。阿魏酸钠可以通过拮抗ET受体、抑制TXA2合成、降低TGF-β、清除自由基、减少炎症介质生成及调节免疫等作用来延缓肾脏损害。两药合用治疗DN疗效显著。
[关键词] 糖尿病肾病；双嘧达莫；阿魏酸钠
[中图分类号] R587.2[文献标识码]B [文章编号]1673-7210(2010)10(a)-064-02
Clinical observation of Dipyridamole and Sodium Ferulate in treatment of diabetes nephrosis
WU Xuan1, YUN Ye2
(1.Mongolian Medicine Chinese Medicine Hospital of Baotou City, Inner Mongolian, Baotou 014040, China; 2.The Fourth Hospital of Baotou City, Inner Mongolian, Baotou 014030, China)
[Abstract] Objective: To observe the level changes of urinate albumin excretion rate (UAER),serum creatinine (SCr), urea nitrogen (BUN), the urine bast element (ET-1) of diabetes nephrosis (DN) patients treated by Dipyridamole and Sodium Ferulate. Methods: 60 cases of DN patients were given Dipyridamole (30 mg/d) and Sodium Ferulate (300 mg/d) based on the diabetes convention treatment and hypodermic Injection Insulin, Dipyridamole and Sodium Ferulate was added into the 200 ml Physiological Saline respectively and intravenous drip, the time of treatment was 4 weeks. Results: After treatment, the UAER, SCr, BUN, ET-1 of patients remarkablely dropped compared with before treatment (all P<0.01). Conclusion: Dipyridamole could suppress the blood platelet function, but also has the expansion of blood vessel, increase the kidney blood stream quantity, reduce the albuminuria, protect the kidney; the Sodium Ferulate may oppress the anti-ET acceptor, suppress the TXA2 synthesis, reduce TGF-β, eliminate free radical, reduce inflammation functions and so on medium production and adjust immunity to delay the kidney harm. And the curative effect is remarkable in the treatment of DN patients with both of them.
[Key words] Diabetes nephrosis; Dipyridamole; Sodium Ferulate ......
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