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3种方案治疗非淋菌性尿道(宫颈)炎的决策树分析(1)
http://www.100md.com 2010年11月15日 李文兵,周亦农,李 清
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     [摘要] 目的:评价3种方案治疗非淋菌性尿道(宫颈)炎的经济学效果。方法:运用药物经济学决策树分析原理,分别对左氧氟沙星序贯疗法、阿奇霉素静脉滴注疗法和依诺沙星静脉滴注疗法进行回顾性分析、评价。结果:3种治疗方案的总成本依次为114.60、474.53和379.33元,总有效率为86.20%、88.35%和87.50%。每治愈1例非淋菌性尿道(宫颈)炎患者所期望的成本分别为132.95、537.10和433.52元。结论:3种治疗方案中以左氧氟沙星序贯疗法为优。

    [关键词] 非淋菌性尿道(宫颈)炎;药物经济学;决策树分析

    [中图分类号] F407.7 [文献标识码] C[文章编号] 1673-7210(2010)11(b)-110-03

    Decision tree analysis of 3 therapeutic schemes for nongonococcal urethritis (cervicitis)

    LI Wenbing1, ZHOU Yi′nong1, LI Qing2

    (1.The Second Hospital of TCM, Guangdong Province, Guangzhou 510095, China; 2.The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China)

    [Abstract] Objective: To evaluate the pharmacoeconomic (PE) efficacies of 3 therapeutic schemes in the treatment of nongonococcal urethritis (cervicitis). Methods: By applying the principle of decision tree analysis in pharmacoeconomics, a retrospective analysis and evaluation was performed on the following 3 therapeutic schemes: sequential therapy of Levofloxacin Injection, Azithromycin for injection by ivgtt and Enoxacin for injection by ivgtt. Results: The total costs of the 3 schemes were 114.60, 474.53 and 379.33 yuan, respectively, and the total effective rates were 86.20%, 88.35% and 87.50%, respectively. The anticipant costs for each cured case of nongonococcal urethritis (cervicitis) were 132.95, 537.10 and 433.52 yuan, respectively. Conclusion: The sequential therapy of Levofloxacin injection is the optimal one among the 3 schemes.

    [Key words] Nongonococcal urethritis (cervicitis); Pharmacoeconomics; Decision trees analysis

    非淋菌性尿道(宫颈)炎(nongonococcal urethritis,NGU)是指通过性接触传播的尿道炎,尿道炎症状明显,但尿道分泌物中查不到淋球菌,是除淋病奈瑟菌外,由多种病原体感染而引起的尿道炎(宫颈炎)的总称,目前被国外学者认可的沙眼衣原体(Ct)与解脲支原体(Uu)只是其中的两种,而其他多种病原体感染也正在引起人们的重视[1]。为最常见的性传播感染疾病之一,其最常见的致病菌为沙眼衣原体和解脲脲原体,治疗多以大环内酯类、四环素类、氟喹诺酮类药物为主,临床及实验室一般将这三类药物作为治疗支原体感染的首选药物[2-3]。为了给临床制订合理用药方案提供决策依据,本文运用决策树原理,对3种治疗非淋菌性尿道(宫颈)炎的方案进行药物经济学分析,现总结如下:

    1 资料与方法

    1.1 一般资料

    选择我院2009年1~12月符合NGU诊断标准[4]的213例门诊患者,随机分为3组;A组(左氧氟沙星序贯疗法),男40例,女32例,平均年龄28.6岁;B组(阿奇霉素静脉滴注疗法),男35例,女30例,平均年龄26.8岁;C组(依诺沙星静脉滴注疗法),男48例,女28例,平均年龄27 ......

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