通腑与泻肺法配伍应用对ALI/ARDS大鼠肺肠组织sIgA含量影响的比较研究(1)
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[摘要] 目的：观察通腑与泻肺法及其配伍应用对ALI/ARDS大鼠肺肠组织sIgA含量的影响。方法：将100只健康wistar大鼠随机分为5组：对照组、模型组、泻肺组、通腑组和通腑泻肺组，采用尾静脉注射油酸加内毒素的方法造成大鼠ALI/ARDS模型，检测各组大鼠肺肠组织sIgA含量。结果：通腑法、泻肺法和通腑泻肺法均可有效降低肺肠组织sIgA含量，且通腑与泻肺法配伍应用效果明显优于二法单独应用。结论：在调节ALI/ARDS大鼠黏膜免疫功能方面，肺肠同治具有明显优势。
[关键词] 通腑泻肺法 ALI/ARDS sIgA 黏膜免疫
[中图分类号] R242 [文献标识码]A[文章编号]1673-7210(2011)02(c)-020-03
The effect of application of combining Tongfu-therapy with Xiefei-therapy on sIgA content in lung and large intestine in ALI/ARDS rats
LIU Enshun1, SUN Zengtao1, SU Jingshen1, GUO Sijia2, LIU Wei1, LIU Jian2, MENG Miaomiao2, YANG Xiao2
(1.Second Affiliated Hospital of Tianjin University of TCM,Tianjin 300150,China;2.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
[Abstract] Objective: To observe the effect of Tongfu-therapy, Xiefei-therapy and Tongfu Xiefei-therapy on sIgA content in lung and large intestine in ALI/ARDS rats. Methods: We divided the health Wistar rats into 5 groups, Control group, model group, lung treatment group, large intestine treatment group and lung-large intestine treatment group. We made the ALI/ARDS-rat model by Intravenous injecting oleic acid and endotoxin in caudal vein, and observed sIgA content in lung and large intestine organs. Results: All of Tongfu-therapy, Xiefei-therapy and Tongfu Xiefei-therapy could effectively reduce the sIgA content in lung and large intestine, and the method of combining Tongfu-therapy with Xiefei-therapy was superior to the single method. Conculsion: Lung-large intestine treatment is great advantage in regulating immunologic function of mucous membrane in ALI/ARDS rats.
[Key words] Tongfu Xiefei-therapy; ALI/ARDS; sIgA; Mucous membrane immunologic function
急性呼吸窘迫综合征(ARDS)是指由心源性以外的各种肺内外致病因素导致的急性进行性缺氧性呼吸衰竭[1]。ARDS的临床表现为进行性呼吸困难、紫绀、气促、喘憋等肺气壅遏的症状，往往同时伴有便秘、腹胀等腑气不通，大肠失于传导的病理变化，其证候学突出体现了中医“肺肠相关”的特点。因此，“肺病及肠”、“肺肠同病”是从中医视角观察ARDS的常见结论，而“脏病治腑”、“通腑泻肺”也是中医常用的有效治法并为临床研究初步证实[2-3]。随着黏膜免疫研究的深入，使人们越来越相信消化系统和呼吸系统两大黏膜器官组织之间存在密切联系，sIgA是黏膜免疫主要的功能执行者，主要存在于初乳、唾液、胃肠液、支气管，这在一定程度上证明了sIgA是联系各处黏膜免疫的共同分子基础。有学者经研究后指出，sIgA是体现肺与大肠相表里的重要物质基础之一[4]。开展通腑与泻肺法及其配伍应用对ALI/ARDS大鼠肺肠组织sIgA含量影响的比较研究，有助于揭示ARDS肺肠相关的免疫调节的物质基础，丰富“肺与大肠相表里”这一脏腑相关理论的现代生物学机制 ......
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