缺血性脑血管病患者血清尿酸水平与颈动脉不稳定斑块的关系
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[摘要] 目的：通过检测124例缺血性脑血管病患者的颈动脉不稳定斑块数与血清尿酸的水平，以探讨血清尿酸水平与颈动脉斑块形成的关系及其在缺血性脑血管病中的意义。方法：选取我院住院患者，分为短暂性脑缺血(TIA)组、脑梗死组，入院24～72 h后行颈动脉超声检查，并于入院次日抽取静脉血，应用ELASA法测定尿酸含量。结果：随着血清中尿酸浓度增高，颈动脉内膜不稳定斑块面积也增大(P<0.05)，且脑梗组血尿酸水平高于TIA组(P<0.05)。结论：尿酸可致颈动脉内膜不稳定斑块面积增大，从而进一步导致缺血性脑血管病的发生。
[关键词] 尿酸；颈动脉斑块；脑血管病
[中图分类号] R714.246[文献标识码]A [文章编号]1674-4721(2011)03(b)-023-02
Relationship of carotid arterial unstable plaque and uric acid level of serum in patients with ischemic cerebrovascular disease
LIU Fei, WANG Yisha
Department of Neurology, Shenzhou Hospital of Shenyang Medical College, Shenyang 110002, China
[Abstract] Objective: To discuss the relationship of the blood serum uric acid level and the carotid artery plaque and the significance in the ICVD, through examining 124 ICVD patients' carotid artery unstable plaque number and the blood serum uric acid level. Methods: The patients in our hospital were collected and divided into the transient ischemic attack group and the cerebral infarction group, we used ultrasound to examine carotid artery unstable plaque. After the patients entering hospital 24-72 h, and the next day, the ELASA was used to examine uric acid concentration. Results: Following the uric acid concentration was higher, the area of the carotid artery internal membrane unstable plaque was larger (P<0.05).The level of uric acid in the serum was higher than that of the cerebral infarction group (P<0.05). Conclusion: The uric acid may increase the carotid artery internal membrane unstable plaque area, then further causes the occurrence of cerebrovascular disease.
[Key words] Uric acid; Carotid artery plaque; Cerebrovascular disease
缺血性脑血管病(ICVD)是常见病和多发病，约占所有疾病死亡人数的10%，具有发病率、死亡率、致残率、复发率高的特点，是目前人类三大死亡原因之一。颈动脉斑块是ICVD的独立危险因素，特别是不稳定斑块易破裂出血形成血栓，或脱落形成栓子造成脑梗死[1]。血清尿酸是人体细胞代谢及食物中嘌呤核糖核酸代谢的终末产物，有文献报道血尿酸水平升高与急性脑血管病的发病率和死亡率相关[2]。本实验检测124例ICVD患者的颈动脉不稳定斑块数与血清尿酸的水平，以探讨血清尿酸水平与颈动脉斑块形成的关系及其在ICVD中的意义，为临床有效防治缺血性脑血管病提供新的依据。
1 资料与方法
1.1 一般资料
选取2009年10月～2010年10月于我院住院的124例ICVD患者 ......
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