喉鳞癌caveolin-1和MVD表达及与颈淋巴结转移的关系
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[摘要] 目的：通过检测124例缺血性脑血管病患者的颈动脉不稳定斑块数与血清尿酸的水平，以探讨血清尿酸水平与颈动脉斑块形成的关系及其在缺血性脑血管病中的意义。方法：选取我院住院患者，分为短暂性脑缺血(TIA)组、脑梗死组，入院24～72 h后行颈动脉超声检查，并于入院次日抽取静脉血，应用ELASA法测定尿酸含量。结果：随着血清中尿酸浓度增高，颈动脉内膜不稳定斑块面积也增大(P<0.05)，且脑梗组血尿酸水平高于TIA组(P<0.05)。结论：尿酸可致颈动脉内膜不稳定斑块面积增大，从而进一步导致缺血性脑血管病的发生。
[关键词] 尿酸；颈动脉斑块；脑血管病
[中图分类号] R714.246[文献标识码]A [文章编号]1674-4721(2011)03(b)-023-02
Relationship of carotid arterial unstable plaque and uric acid level of serum in patients with ischemic cerebrovascular disease
LIU Fei, WANG Yisha
Department of Neurology, Shenzhou Hospital of Shenyang Medical College, Shenyang 110002, China
[Abstract] Objective: To discuss the relationship of the blood serum uric acid level and the carotid artery plaque and the significance in the ICVD, through examining 124 ICVD patients' carotid artery unstable plaque number and the blood serum uric acid level. Methods: The patients in our hospital were collected and divided into the transient ischemic attack group and the cerebral infarction group, we used ultrasound to examine carotid artery unstable plaque. After the patients entering hospital 24-72 h, and the next day, the ELASA was used to examine uric acid concentration. Results: Following the uric acid concentration was higher, the area of the carotid artery internal membrane unstable plaque was larger (P<0.05).The level of uric acid in the serum was higher than that of the cerebral infarction group (P<0.05). Conclusion: The uric acid may increase the carotid artery internal membrane unstable plaque area, then further causes the occurrence of cerebrovascular disease.
[Key words] Uric acid; Carotid artery plaque; Cerebrovascular disease
颈淋巴结转移是影响喉鳞状细胞癌患者预后的关键因素。近年研究发现肿瘤内血管生成促进肿瘤浸润和转移，在肿瘤血管生成中，caveolin-1发挥重要的作用，但caveolin-1在喉鳞状细胞癌转移中的研究较少。本实验将从基因和蛋白水平探讨caveolin-1在喉癌血管生成和肿瘤转移中的作用，为肿瘤的预防和治疗提供新的临床策略。
1 材料与方法
1.1 材料
选取我科2008年8月～2010年9月期间手术切除的标本，20例不伴有颈淋巴结转移的喉鳞状细胞癌组织(第1组)，20例伴有颈淋巴结转移的喉鳞状细胞癌组织(第2组)。所有喉鳞癌患者均为初发，术前均未接受任何放射或化学治疗，每个喉标本在术后立即取材，所取标本切除均经患者及患者家属同意。caveolin-1多抗购自美国Santa Cruz公司，CD34抗体和小鼠二步法检测试剂盒购自中杉金桥公司 ......
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