苦参素胶囊联合阿德福韦酯治疗HBeAg阳性慢性乙型肝炎疗效观察
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[摘要] 目的：观察苦参素胶囊联合阿德福韦酯治疗HBeAg阳性慢性乙型肝炎(CHB)的临床效果。方法：选择HBsAg、HBeAg、HBV DNA持续阳性半年以上，HBV DNA≥1.0×105 copies/ml，ALT大于正常上限2倍以上，TBil升高小于正常上限3倍的CHB患者104例，随机分为两组，对照组50例，给予阿德福韦酯胶囊 10 mg，1次/d,口服。治疗组54例，在对照组基础上给予苦参素胶囊0.3，3次/d，口服。两组对症治疗措施相似，均不用其他抗病毒、免疫调节及抗肝纤维化制剂，疗程共9个月。观察肝功能(ALT、TBil)、乙肝病毒指标(HBsAg、HBeAg、HBV DNA)及肝纤维化指标(HA、LN、ⅣC)的变化。结果：治疗组肝功能复常率、乙肝病毒指标阴转率均高于对照组。两组比较差异有统计学意义(P<0.05)。肝纤维化指标两组治疗前比较，差异无统计学意义(P>0.05)；治疗组治疗后与对照组比较差异有统计学意义(P<0.01)，与治疗前比较差异有高度统计学意义(P<0.01)。结论：苦参素胶囊联合阿德福韦酯治疗HBeAg阳性CHB患者，在肝功能复常、乙肝病毒指标阴转及肝纤维化指标改善方面均有显著作用。
[关键词] 慢性乙型肝炎；HBeAg阳性；苦参素；阿德福韦酯
[中图分类号] R512.6+2[文献标识码]A [文章编号]1673-7210(2011)03(b)-062-03
Therapeutic effect of HBeAg positive chronic hepatitis B treated by Kurorinone Capsule combined with Adefovir Dipivoxil Capsule
LU Minglei, LIU Qin, JIA Qiulong
Xinxiang Hospital of Infectious Diseases, Xinxiang 453000, China
[Abstract] Objective: To observe the clinical effects of Kurorinone Capsule combined Adefovir Dipivoxil Capsule in treating of patients with HBeAg positive chronic hepatitis B (CHB). Methods: To choose 104 CHB patients with HbsAg, HbeAg, HBV DNA remaining positive for more than six months, HBV DNA≥1.0×105 copies/ml, ALT was more than 2 times upper limit of normal, TBil increased less than 3 times upper limit of normal. These patients were randomly divided into two groups, 50 patients of the control group were given with Adefovir Dipivoxil Capsule, 10 mg，1 time/d, oral route. On the basis of the treatment of the control group, 54 patients of the treatment group were given with Kurorinone capsule 0.3, 3 times/d, oral route. Symptomatic treatment measures were similar of the two groups, other anti-virus, immunity adjusting and Anti-hepatic fibrosis preparation were not used in both groups ......
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