米索前列醇联合米非司酮伍用依沙吖啶用于中期引产临床疗效观察
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[摘要] 目的：探讨米索前列醇和米非司酮用于中期引产的临床效果，为临床应用提供数据支持。方法：回顾性分析2008年10月～2010年10月我院采用米索前列醇和米非司酮进行引产的122例中期妊娠患者(观察组)的临床资料，并与单纯使用依沙吖啶进行中期引产的122例患者为对照组，对比两组患者宫颈松弛效果、总产程、产后出血量、软产道损伤发生率以及清宫率等情况。结果：观察组引产成功率为93.44%，对照组引产成功率为87.70%，组间比较差异有统计学意义(P<0.05)；观察组药物不良反应发生率为7.38%，对照组为13.11%，组间比较差异有统计学意义(P<0.05)。结论：米非司酮联合米索前列醇用于中期妊娠引产具有产程短、出血量小、成功率高、安全、患者痛苦少等优点，值得临床推广。
[关键词] 米非司酮；米索前列醇；依沙吖啶；中期妊娠
[中图分类号] R719.3+1 [文献标识码]A[文章编号]1673-7210(2011)03(b)-075-02
Clinical curative effect observation of Misoprostol combined with Mifepristone in accordance with Ethacridine for medium-term induced labor
LIU Xueyan
Department of Obstetrics and Gynecology, The People′s Hospital of Wei County, Xingtai 054700, China
[Abstract] Objective: To explore the clinical effect of Misoprostols and Mifepristone used in medium-term induced labor, to provide data for clinical application. Methods: The clinical data of Misoprostol combined with Mifepristone were induced for 122 patients midtrimester induction of labor (observation group) was retrospectively analysed from October 2008 to October 2010, And with simple used Ethacridine for 122 patients midtrimester induction of labor as control group, total labor, postpartum bleeding, macrosomic infant damage incidence and curettage rate etc were compared in two groups. Results: The rate of labor success of observation group was 93.44%, the control group was 87.70%, there was a significant difference between two groups (P<0.05); drug adverse reaction rate of the observation group was 7.38%, the control group was 13.11%, there was statistically significant differences between two groups (P<0.05). Conclusion: Mifepristone combined with Misoprostol used for medium-term pregnancy induced labor has short, little bleeding, high success rate, safety, less painful and is worth clinical promotion.
[Key words] Mifepristone; Misoprostol; Ethacridine; Medium-term pregnancy
中期引产是指妊娠14～24周因各种原因需要用人工方法中止妊娠使胎儿产出的临床过程。随着我国社会生活节奏的加快和人们婚育观念的改变，采用人工方法中止妊娠的情况越来越多，而且人们对引产质量的要求越来越高。米非司酮为新型抗孕激素，并无孕激素、雌激素、雄激素及抗雌激素活性，能与孕酮受体及糖皮质激素受体结合，对子宫内膜孕酮受体的亲和力比黄体酮强5倍 ......
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