营养不良风险的慢性乙型肝炎患者甲胎蛋白\高尔基体糖蛋白73表达分析(1)
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[摘要] 目的：研究应用营养筛查评分简表(NRS2002)评分在甲胎蛋白(AFP)、高尔基体糖蛋白73(GP73)高表达的患者中的应用价值。方法：对206例肝炎患者体重指数(BMI)、白蛋白、AFP、GP73的测定，利用NRS2002评分简表对患者进行评分，将患者分成营养风险组(A组)和非营养风险组(B组)，采用统计学方法对A、B组两组患者的AFP、GP73表达进行分析。结果：营养风险组所检测的AFP、GP73高表达率显著高于非营养风险组(P<0.05)；营养风险组的CHB、肝硬化、原发性肝癌(PHC)患者AFP、GP73的表达逐渐增加；NRS2002分值越高，AFP、GP73表达亦增高。结论：结合NRS2002评分能更多地将无AFP、GP73高表达的患者被正确区分，从而提高AFP、GP73高表达的检出率。
[关键词] 慢性活动性肝炎；营养风险筛查(2002)；甲胎蛋白；高尔基体糖蛋白73
[中图分类号] R512.6[文献标识码]A[文章编号]1673-7210(2011)04(b)-023-03
Analysis of the Expression of GP73 and AFP in Chronic Hepatitis B Patients with Malnutrition Risks
WENG Tianbo1, TAN Yizhou2, ZHOU Guihua3, HU Fengyu2, CHEN Qiuxiang4, CHEN Xing2, CHEN Ran2
1.Nutritional Department, the Eighth People′s Hospital of Guangzhou City, Guangzhou 510060, China; 2.Department of Clinical Laboratory, the Eighth People′s Hospital of Guangzhou City, Guangzhou 510060, China; 3.Surgercal Department, Yayao Hospital of Huadu District in Guangzhou City, Guangzhou 510080, China; 4.Department of Hepatopathy, the Eighth People's Hospital of Guangzhou City, Guangzhou 510060, China
[Abstract] Objective: To investigate the value of using NRS2002 to grade patients with high expression of AFP and GP73. Methods: With the help of NRS2002, the patients were classified into nutrition risk group (A) and non-nutrition group (B) after testing the BMI, albumin, AFP, and GP73 of 206 hepatitis patients. By means of statistical methods, the expression of AFP and GP73 of these two groups will be analyzed. Results: The expression rate of AFP and GP73 detected in group A were remarkably higher than that in group B (P<0.05); the expression of AFP and GP73 of those patients suffered from CHB, cirrhosis and PHC in the former group increased gradually, demonstrating a tendency of higher expression of AFP and GP73 with a higher grade in NRS. Conclusion: Integrated with the grading system of NRS2002, more patients without high expression of AFP and GP73 will be differentiated so as to improve the detection rate of high expression of AFP and GP73.
[Key words] CHB; Nutritional risk screening (NRS2002); AFP; GP73
我国是肝炎大国，为肝癌的发生提供了庞大的基数人群。据新近统计，世界上每新增2例肝癌就有1例发生在中国，严重威胁着我国公众的生命健康，并给国家医疗资源带来了巨大负担。肝癌也是我国位居第二的癌症“杀手”，患者早期一般没有什么不适，一旦出现症状就诊，往往已属中晚期，一般发病后生存时间仅为6个月，人称“癌中之王”。因此肝癌的防治着重在于预防与早期诊断。营养不良与恶性肿瘤密切相关，而欧洲肠内营养学会(ESPEN)于2002年提出，并推荐使用营养筛查(nutritional Risk screening 2002，NRS2002)工具。应用NRS2002工具对患者营养风险进行筛查，信度和效度在欧洲已得到验证[1] ......
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