双歧杆菌防治极低出生体重儿坏死性小肠结肠炎的作用研究(1)
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[摘要] 目的：观察应用双歧杆菌预防极低出生体重儿坏死性小肠结肠炎(NEC)的有效性。方法：回顾性分析2005年1月～2008年5月在我院NICU住院治疗的生后存活7 d并且开始胃肠道喂养的极低出生体重儿183例的临床资料。结果：预防组NEC发病率为2.10%(2/95)，对照组NEC发生率为11.36%(10/88)，两组比较差异有统计学意义(P<0.01)。住院期间预防组每日体质量增加(8.108±2.205)g，对照组为(6.256±2.298)g，两组比较差异有统计学意义(P<0.01)。治疗后7 d两组患儿肠道细菌总数、杆菌、球菌总数及杆球菌比值差异均有统计学意义(P<0.01)。预防组治疗前、治疗后7 d杆球菌比值差异无统计学意义(P>0.05)。治疗前两组患儿大便双歧杆菌数的比较差异均无统计学意义(P>0.05)；治疗后7 d两组患儿大便双歧杆菌数的比较差异有统计学意义(P<0.01)。预防组治疗前、治疗后7 d大便双歧杆菌数的比较差异有统计学意义(P<0.01)；对照组治疗前、治疗后7 d大便双歧杆菌数的比较差异无统计学意义(P>0.05)。结论：给予极低出生体重儿预防性口服双歧杆菌能够降低NEC发病率，促进其体质量增长。其机制与口服双歧杆菌后促进新生儿肠道正常菌群的定植和优势化、维持肠道正常菌群比率有关。
[关键词] 坏死性小肠结肠炎；极低出生体重儿；微生态制剂；双歧杆菌
[中图分类号] R656.7[文献标识码]A [文章编号]1673-7210(2011)04(b)-035-03
A research on the effect of bifidobacterium in the field of preventing and curing the NEC of very low birth weight children
HUANG Baizhi, LIU Fang
1.Guangdong Medical College, Zhanjiang 524023, China; 2.Department of Microbiology and Immunology, Guangdong Medical College, Zhanjiang 524023, China
[Abstract] Objective: To observe the preventing effectiveness of applying bifidobacterium to very low birth weight children with NEC. Methods: The clinical data of 183 patients of NICU hospitalization survival 7 d after birth and fed the gastrointestinal tract of very low birth weight children in our hospital from January 2005 to May 2008 were retrospectively analyzed. Results: From the results, the NEC incidence rate of the preventive group was 2.10% (2/95), while the control group was 11.36% (10/88); the daily weight increase of the preventive group was (8.108±2.205) g, while the control group was (6.256±2.298) g. There were statistical significance in the comparison of both groups (all P<0.01). In addition, 7 days after treatment, the total number of patients′ intestinal bacteria, bacilli, cocci and the comparison value of bacilli and cocci, as well as the comparison of the total number of stool bifidobacterium from patients of both groups and from preventive group′s patients before and after treatment, there were significant differences(P<0 ......
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