干扰素α-2a治疗慢性乙肝患者血清Th1/Th2亚群细胞因子的水平变化及意义(1)
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[摘要] 目的：探讨干扰素(IFN-α)治疗慢性乙型肝炎(乙肝)抗病毒疗效与Th细胞因子的变化关系。方法：回顾性分析我院2008年4月～2010年10月收治入院的慢性乙肝患者90例的临床资料，90例的患者均采用IFN-α治疗(HBeAg阳性组)，以90例健康献血员作为正常HBeAg阴性组。ELISA法检测治疗1 年后患者外周血HBV-DNA及Th细胞因子IL-2、IFN-γ、IL-4、IL-10。结果：HBeAg阳性组治疗后血清IL-2、IFN-γ均值明显升高(P<0.05)，HBV-DNA含量均值明显下降(P<0.05)； HBeAg阳性组治疗前血清IL-2、IFN-γ与HBeAg阴性组比较均值明显升高(P<0.001)，IL-4、HBV-DNA含量均值明显下降(P<0.001)。HBeAg阳性组治疗后血清IL-2、IFN-γ与HBeAg阴性组比较均值明显升高(P<0.01)，IL-4、HBV-DNA含量均值明显下降(P<0.01)。结论：IFN-α治疗慢性乙型肝炎可显著抑制HBV-DNA复制；治疗后有效组免疫状态可由以Th2型为主向以Th1型为主转换。
[关键词] 干扰素；慢性乙型肝炎；Th细胞因子
[中图分类号] R512.62 [文献标识码] A [文章编号] 1673-7210(2011)07(a)-022-03
Level changing and significance of Interferon α-2a in the treatment of chronic hepatitis B subsets Th1/Th2 cytokines
GU Bin
The Second People's Hospital of Chenzhou City in Hu'nan Province, Chenzhou 423000, China
[Abstract] Objective: To explore the relationship of Th cytokines and antiviral efficacy of Interferon (IFN-α) in the treatment of chronic hepatitis B (HBV). Methods: The clinical data of 90 patients with chronic hepatitis B in our hospital from April 2008 to October 2010 were retrospectively analyzed. 90 patients were treated with IFN-α (HBeAg-positive group), 90 healthy blood donors as normal HBeAg negative group. After treatment of one year, the patients with HBV-DNA and the Th cytokines IL-2, IFN-γ, IL-4, IL-10 were detected by ELISA assay. Results: HBeAg-positive group after treatment, serum IL-2, IFN-γ increased (P<0.05), HBV-DNA levels decreased (P<0.05); HBeAg positive before treatment serum IL-2, IFN-γ compared with HBeAg-negative group was significantly higher than the average (P<0.001), IL-4, HBV-DNA the mean levels significantly decreased (P<0.001). Serum HBeAg-positive group after treatment, IL-2, IFN-γ compared with HBeAg-negative group were significantly higher (P<0.01), IL-4, the mean levels of HBV-DNA significantly decreased (P<0.01). Conclusion: IFN-α treatment of chronic hepatitis B can significantly inhibit HBV-DNA replication; effective group after treatment with Th2-type immune status can be mainly oriented to the Th1-type conversion ......
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