阻塞性睡眠呼吸暂停综合征与心血管疾病的临床观察(1)
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[摘要] 目的：探讨阻塞性睡眠呼吸暂停综合征(OSAS)与心血管疾病发病的关系。方法：应用多导睡眠监测仪研究58例OSAS患者(设为观察组)夜间心律、血压以及PSG检测参数的动态变化，以同期30例健康体检者作为对照组，对两组监测指标进行比较。结果：观察组室性早搏次数为(784.15±39.16)次，室上性早搏次数为(198.09±9.14)次，与对照组的(219.42±17.03)和(193.58±15.25)次比较，差异有统计学意义(P<0.05)；观察组最长呼吸暂停时间为(62.05±24.68)s、平均呼吸暂停时间为(40.69±15.23)s、呼吸紊乱次数为(362.83±39.16)次、呼吸紊乱指数为(58.39±10.35)、低氧频率为(407.82±85.26)、低氧指数为(65.42±15.36)，SaO2为(86.32±12.89)%，平均动脉压为(129.05±12.73)mm Hg，与对照组比较，差异均有统计学意义(均P<0.05)。结论：OSAS可导致心血管系统的异常，进一步探讨OSAS的病因并加以防治，对心血管病的防治具有重要意义。
[关键词] 阻塞性睡眠呼吸暂停综合征；心血管疾病；高血压；心律失常
[中图分类号] R766 [文献标识码] A [文章编号] 1673-7210(2011)07(a)-045-02
Clinical observation of obstructive sleep apnea syndrome and cardiovascular disease
LAI Fangfang
The People′s Hospital of Xingning City, Guangdong Province, Xingning 514500, China
[Abstract] Objective: To investigate the relationship of obstructive sleep apnea syndrome (OSAS) and heart disease pathogenesis. Methods: Polysomnography was used to monitor nocturnal heart rhythm blood pressure and the dynamic change of testing parameters of PSG of 58 patients with OSAS, 30 healthy persons in the same period were used as control group. The index of two groups were compared. Results: OSAS patients′ premature ventricualr contraction occurrence was (784.15±39.16) times, and supraventricular contraction was (198.09±9.14) times, which were all significantly lower than those of the control group (219.42±17.03) and (193.58±15.25) times (P<0.05); OSAS group patients' longest apnea time was (62.05±24.68) s, mean apnea time was (40.69±15.23) s, the number of respiratory disorders was (362.83±39.16) times, respiratory disturbance index was (58.39±10.35), oxygen frequency (407.82±85.26), low oxygen index was (65.42±15.36), and SaO2 was (86.32±12.89)%, the blood pressure was (129.05±12.73) mm Hg, there were a significant differences compared with those of the control group (P<0.05). Conclusion: Obstructive sleep apnea syndrome can lead to abnormal cardiovascular system, further explore the etiology of OSAS, and the control of the heart vascular disease prevention have great significance ......
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