神经节苷脂治疗早产儿颅内出血致脑损伤的临床研究(1)
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[摘要] 目的：观察神经节苷脂辅助治疗早产儿颅内出血所致的脑损伤的临床效果。方法：将98例颅内出血致脑损伤患儿随机分为治疗组和对照组，每组49例。对照组采用综合治疗，治疗组在综合治疗的同时加入神经节苷脂进行干预治疗，观察并比较两组的临床疗效及其行为神经评分(NBNA评分)。结果：治疗组49例患儿中，38例(77.55%)显效，总有效率为95.92%；对照组24例(48.98%)显效，总有效率为77.55%。两组显效率和总有效率比较，差异均有统计学意义(P<0.05)；20项NBNA测定结果显示，两组患儿在治疗1个疗程以后，NBNA评分均有改善，但治疗组改善显著优于对照组(P<0.05)。结论：神经节苷脂治疗早产儿颅内出血致脑损伤有较好的临床疗效，可以显著降低患儿的病死率和神经系统后遗症的发生率。
[关键词] 颅内出血；新生儿；神经节苷脂；神经系统后遗症
[中图分类号] R722 [文献标识码] A [文章编号] 1673-7210(2011)07(a)-070-02
The clinical research of ganglioside to preterm children with brain damage caused by intracranial hemorrhage
LAI Longlong, ZHANG Xudong
Shanwei Yihui Foundation Hospital, Guangdong Province, Shanwei 516600, China
[Abstract] Objective: To observe the clinical effect of ganglioside to preterm children with brain damage induced by intracranial hemorrhage. Methods: 98 cases with intracranial hemorrhage induced brain injury were randomly divided into treatment group and control group, with 49 patients in each group. The control group was treated with integrated therapy, while the treatment group added ganglioside based on the integrated treatment, the clinical efficacy and NBNA score of the two groups were observed and compared. Results: Among the 49 cases of the treatment group, 38 (77.55%) cases were markedly effective, the total effective rate was 95.92%; In the control group, 24 (48.98%) cases were markedly effective, with a total effective rate 77.55%. The efficiency and total efficiency of two groups were significantly different (P<0.05); NBNA determination results showed that the NBNA scores of the two groups both improved, but that of the treatment group improved significantly than control group (P<0.05). Conclusion: Ganglioside has better clinical effect for children with intracranial hemorrhage induced brain injury, which can significantly reduce mortality and the incidence of neurological sequelae.
[Key words] Intracranial hemorrhage; Newborn; Ganglioside; Neurological sequelae
我国早产儿的发生率为5%～10%，由于其胎龄较小、体重较轻，早产儿的后遗症较多，尤其是颅内出血(intracranial hemorrhage，ICH)，是引起早产儿死亡和神经系统功能障碍的重要原因[1]。相关研究证明，神经节苷脂(GAS)是一种脑神经保护剂 ......
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