血清铁蛋白联合D-二聚体检测对脑梗死患者的诊断价值(1)
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[摘要] 目的：研究脑梗死患者血清内D-二聚体和铁蛋白含量对脑梗死诊断的意义。方法：选择我院2008～2010年脑梗死患者215例为治疗组，正常门诊体检者215例为对照组，行血清内D-二聚体和铁蛋白检测比较，尿激酶溶栓后再次检测存活的209例脑梗死患者溶栓前后体内D-二聚体和铁蛋白含量。结果：治疗组中，有6例在研究过程中死亡，1例死于脑疝，3例死于肺部感染，2例死于脑梗死合并下壁心肌梗死。正常人与脑梗死患者D-二聚体含量比较差异具有高度统计学意义(t=7.325，P<0.01)；正常人与脑梗死患者血清含铁蛋白比较，差异有高度统计学意义(t=7.923，P<0.01)。尿激酶溶栓后，治疗组所有存活病例的血清D-二聚体较溶栓前明显增加(t=8.301，P<0.01)；治疗后血清铁蛋白较治疗前明显减少(t=9.627，P<0.01)。结论：血清内D-二聚体和铁蛋白含量是检测脑梗死患者病情的敏感值，其与脑梗死受损及恢复程度有密切关系。
[关键词] 血清铁蛋白；D-二聚体；脑梗死
[中图分类号] R743 [文献标识码] B [文章编号] 1673-7210(2011)07(a)-088-02
Clinical diagnostic value of serum ferritin united with plasma D-Dimer test in patients with cerebral infarction
CHEN Yongjian
Department of Emergency, the Center Hospital of Jiangmen City, Guangdong Province, Jiangmen 529030, China
[Abstract] Objective: To investigate the clinical significance of serum ferritin and plasma D-dimer in diagnosing cerebral infarction. Methods: To select 215 cases of cerebral infarction patients in our hospital from 2008 to 2010 as treatment group, 215 cases of normal people as control group, and to compare serum ferritin and D-dimer in two groups. Then compare serum ferritin and D-dimer results of live cerebral infarction patients before and after urokinase thrombolysis therapy. Results: 6 cases died during the therapy among the 215 patients, 1 patients died of cerebral hernia, 3 cases died of lung infection, 2 cases died of cerebral infarction with myocardial infarction. The differences of D-dimer between the two groups had statistical significance (t=7.325, P<0.01). There were significant differences between the normal and patients in serum ferritin as well (t=7.923, P<0.01). And D-dimer of live cerebral infarction patients increase obviously after thrombolysis therapy (t=8.301, P<0.01), the serum ferritin decreased obviously (t=9.627, P<0.01). Conclusion: The test results of serum ferritin and D-dimer are sensitive to diagnose cerebral infarction, and closely related with the recovery and prognosis.
[Key words] Serum ferritin; D-dimer; Cerebral infarction
脑梗死是由脑动脉阻塞后出现相应部位脑组织的破坏，可伴发出血。发病机制为血栓形成或栓塞 ......
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