子宫内膜异位症术后应用促性腺激素释放激素孕三烯酮和米非司酮的疗效比较(1)
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[摘要] 目的：探讨子宫内膜异位症患者保守性手术后应用不同药物治疗的临床疗效。方法：选择行保守性手术的盆腔子宫内膜异位症患者122例，随机分为三组。GnRH-a组40例，孕三烯酮组40例，米非司酮组42例。分析并比较术后应用GnRH-a、孕三烯酮和米非司酮治疗子宫内膜异位症的疗效，妊娠率，监测内分泌变化。结果：GnRH-a组临床完全缓解率(92.5%)和妊娠率(75.0%)明显高于孕三烯酮组(82.5%、50.0%)和米非司酮组(83.3%、54.5%)(P<0.05)，但三组间的复发率差异不明显(P>0.05)。GnRH-a组用药后，血清LH、FSH、E2水平均显著下降(P<0.05)，孕三烯酮组和米非司酮组各项检测指标比较，差异无统计学意义(P>0.05)。用药后，GnRH-a组血清LH、FSH、E2水平与其他两组相比较，差异有统计学意义(P<0.05)。结论：术后应用GnRH-a可以提高患者受孕率，是一种有效的临床治疗方法。
[关键词] 子宫内膜异位症；促性腺激素释放激素；孕三烯酮；米非司酮
[中图分类号] R711.71[文献标识码]A [文章编号]1673-7210(2011)07(c)-045-03
Comparison the effects of endometriotic patients treated with GnRH-a, gestrinone and mifepristone after conservative surgery
LIN Chunlian
Maternal and Child Health Hospital Fertility Center of Qinzhou City, Guangxi Zhuang Autonomous Region, Qinzhou 535000, China
[Abstract] Objective: To investigate the efficacy of gonadotropin releasing hormone, gestrinone and mifepristone on endometriotic patients after conservative surgery. Methods: 122 women with endometriosis after conservative surgery were divided into three groups randomly. 40 cases in the group of gonadotropin releasing hormone (GnRH-a), 40 cases in the gestrinon group, 42 cases in the mifepristone group. The remission rate, pregnancy rate and the level of sex hormone before and after treatment were compared. Results: The remission rate and the pregnancy rate of GnRH-a group (92.5% and 75.0%) were higher than that in gestrinon and mifepristone group (82.5%, 50.0% and 83.3%, 54.5%), the difference were significantly (P<0.05). The recurence rate of these group was no significant difference (P>0.05). The level of LH, FSH, E2 were lower than that before treatment (P<0.05). But there were no changes before and after treatment in gestrinon and mifepristone group (P>0.05). However, the level of LH, FSH, E2 in group A were lower than that in gestrinon and mifepristone group (P<0.05). Conclusion: After conservative surgery, GnRH-a can increase the rate of conception, which is an effective method.
[Key words] Endometriosis; Gonadotropin releasing hormone; Gestrinone; Mifepristone
子宫内膜异位症(endometriosis ......
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