急性心肌梗死溶栓治疗前后YKL-40的变化及意义(1)
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[摘要] 目的：探讨血清甲壳质酶蛋白40(YKL-40)在非ST段抬高心肌梗死和ST段抬高心肌梗死溶栓再通前后的变化及意义。方法：测定17例ST段抬高心肌梗死患者溶栓前及再通后YKL-40的水平，18例非ST段抬高心肌梗死患者YKL-40水平及20例健康状况良好、未发现心脏相关疾病健康体检者血清中的YKL-40，分别比较ST段抬高心肌梗死溶栓前与非ST段抬高心肌梗死及健康体检者的差异以及ST段抬高心肌梗死溶栓再通前后的差异。结果：ST段抬高心肌梗死患者溶栓前血清YKL-40水平[(157.56±52.35)μg/L(75.02～558.04 μg/L)]，显著高于健康体检组[(97.3±36.04)μg/L(53.2～199.05 μg/L)](P<0.05)和非ST段抬高心肌梗死组[(124.3±41.12)μg/L(67.5～224.8 μg/L)](P<0.05)；健康体检者组与非ST段抬高心肌梗死组比较，差异有统计学意义(P<0.05)。溶栓再通后YKL-40水平为[(106.45±39.22)μg/L(64.13～159.24 μg/L)]，与溶栓前比较，差异有统计学意义(P<0.05)。溶栓再通后与健康体检者组比较，差异无统计学意义(P>0.05)。结论：血清YKL-40水平检测在急性心肌梗死的早期诊断、治疗效果方面有较大的临床价值。
[关键词] 血清甲壳质酶蛋白40；急性心肌梗死；溶栓
[中图分类号] R542.2[文献标识码]A [文章编号]1673-7210(2011)07(c)-060-03
Changes and significance of YKL-40 after thrombolytic therapy for acute myocardial infarction
ZHOU Li, SUN Honglei, BI Meijuan
Cardiovascular Department, the Central Hospital of Jiaozuo Coal Group, He′nan Province, Jiaozuo 454100, China
[Abstract] Objective: To investigate the changes and its significance caused by serum enzyme chitin 40 (YKL-40) after thrombolytic therapy for non-ST-segment elevation myocardial infarction and ST-segment elevation myocardial infarction. Methods: The serum YKL-40 levels of 17 patients with ST-segment elevation myocardial infarction before and after thrombolytic treatment, 18 patients with non-ST-segment elevation myocardial infarction and 20 healthy people without any detected heart related diseases were detected. The patients with ST-segment elevation myocardial infarction before thrombolytic treatment was compared to patients with non-ST-segment elevation myocardial infarction, healthy people and patients with ST-segment elevation myocardial infarction after thrombolytic treatment. Results: The serum YKL-40 level of patients with ST-segment elevation myocardial infarction before thrombolytic treatment was [(157.56±52.35) μg/L(75.02-558.04 μg/L)], which was significantly higher than [(97 ......
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