美托洛尔联合西拉普利治疗慢性充血性心力衰竭的疗效观察(1)
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[摘要] 目的：探讨美托洛尔联合西拉普利治疗慢性充血性心力衰竭(CHF)患者的临床疗效。方法：将CHF患者86例随机分为观察组和对照组，每组各43例，对照组给予常规利尿剂、地高辛、硝酸盐、螺内酯等抗心力衰竭药物进行治疗，观察组则在对照组基础上，加用美托洛尔联合西拉普利治疗，两组患者6个月为1个疗程。并观察患者心功能分级、左室舒张末期内径、收缩末期内径、左室射血分数。结果：观察组总有效率为97.67%(42/43)，对照组则为79.07%(34/43)，两组比较差异有统计学意义(P<0.05)。结论：在强心利尿的基础上，美托洛尔联合西拉普利治疗CHF可明显改善患者左心室功能等临床症状，其临床治疗效果显著。
[关键词] 慢性充血性心力衰竭；美托洛尔；西拉普利
[中图分类号] R541.6[文献标识码]A [文章编号]1673-7210(2011)07(c)-081-02
The observation of curative effect on Metoprolol combined with Cilazapril in treatment of chronic congestive heart failure
KONG Haihong
Department of Emergency, Lecong Hospital of Shunde District in Foshan City, Guangdong Province, Foshan 528315, China
[Abstract] Objective: To discuss the clinical effect of Metoprolol combined with Cilazapril in treatment of chronic congestive heart failure. Methods: 86 cases of CHF patients were randomly divided into observation group and control group, with 43 cases in each group, the control group was treated by routine diuretic, Digoxigenin, nitrate, Spironolactone and somedrug else which resisted heart failure. The observation group was treated on the basic of control group and added Metoprolol combined with Cilazapril. 6 months for one cycle. To observe patients′cardiac dysfunctions grading, left ventricular end diastolic internal diameter, end systolic internal diameter, Left ventricular ejection fraction. Results: The total of effective rate of the observation group was 97.67% (42/43), the control group of 79.07% (34/43), and there were statistical significance between two groups (P<0.05). Conclusion: On the basis of cardiacdiuretic, Metoprolol combined with Cilazapril in treatment of CHF can improve patients′left ventricular function and some other clinic symptoms, which have significantly clinical effect.
[Key words] Chronic congestive heart failure; Metoprolol; Cilazapril
慢性充血性心力衰竭(CHF)是由于多种不同疾病因素引起的心脏收缩和舒张功能受损，其中以心脏排血量缺乏，组织的血液灌注减少以及肺循环或体循环静脉系统淤血为特征，它是一种临床综合征，预后差、病死率高[1]。CHF 是严重影响人类健康的重要疾病之一，伴随着我国经济的高速发展，高血压、冠心病等疾病的发病率逐渐增加，心脏疾病终末阶段的CHF患者人数急剧增多。而随着心力衰竭(HF)严重程度的增加，致使CHF加重而导致死亡的患者也在不断增多。CHF患者总体预后极差，因此，对CHF的治疗则就显得尤其重要[2]。本研究在强心利尿常规治疗的基础上加用美托洛尔联合西拉普利治疗CHF ......
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