[摘要] 阿糖胞苷作为治疗儿童急性髓性白血病的化学治疗药物的主要药物之一，其作用机制得到深入研究。近年来，随着大剂量阿糖胞苷在急性髓性白血病化疗过程中的广泛应用，其高浓度依赖性毒副作用日益严重。如何选用最佳剂量及疗程是大剂量阿糖胞苷治疗儿童急性髓性白血病的关键问题。本文将对大剂量阿糖胞苷治疗儿童急性髓性白血病的发展现状作一综述。

    [关键词] 急性髓性白血病；儿童；大剂量阿糖胞苷

    [中图分类号] R733.71[文献标识码]A [文章编号]1673-7210(2011)08(a)-008-02

    Current situation of high-dose cytarabine in treatment of children with acute myeloid leukemia

    HU Jingwen, YU Yalian, HUANG Jiazhen

    China Medical University Clinical Medicine Department (Seven-years System), Liaoning Province, Shenyang 110004, China

    [Abstract] Cytarabine is used as one of the main durgs to treat the acute myeloid leukemia and its mechanism of action has been investigated further. The superiority of high-dose cytarabine has been thought highly in the recent years, but the adverse effects can not be avoided. This paper will review the current situation of high-dose cytarabine in treatment of children with acute myeloid leukemia.

    [Key words] Acute myeloid leukemia; Childhood; High-dose cytarabine

    白血病是儿童最常见的恶性血液肿瘤 ......