托特罗定对膀胱细胞兴奋性的影响及在膀胱收缩功能中作用的探讨(1)
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[摘要] 目的：探讨托特罗定对膀胱细胞兴奋性的影响及其在膀胱收缩功能中的作用，为膀胱活动过度症的治疗提供参考。方法：将膀胱活动过度症患者80例随机分为治疗组与对照组，每组各40例，治疗组给予托特罗定治疗，对照组给予黄酮哌酯治疗。结果：两组治疗后24 h平均排尿次数和平均单次排尿量较治疗前，差异均有统计学意义(均P<0.05)；治疗组治疗后24 h平均排尿次数明显少于对照组(t=9.363，P<0.05)，平均单次排尿量明显多于对照组(t=12.363，P<0.05)；治疗后，治疗组的临床总有效率为95%(38/40)，对照组临床总有效率为75%(30/40)，治疗组的临床总有效率明显高于对照组(χ2=6.336，P<0.05)，差异有统计学意义。两组口干、便秘、烦躁等不良反应发生率差异无统计学意义(P>0.05)。结论：托特罗定在治疗膀胱活动过度症的应用中能明显降低膀胱细胞的兴奋性与收缩功能，提高治疗疗效，且无明显不良反应，值得推广应用。
[关键词] 托特罗定；膀胱活动过度症；膀胱细胞；膀胱收缩功能
[中图分类号] R694 [文献标识码] A [文章编号] 1673-7210(2011)11(b)-066-02
The influence of Tolterodine on bladder cell excitability and bladder contraction
TAN Yong
Department of Urology, the People's Hospital of Shapingba District in Chongqing City, Chongqing 400030, China
[Abstract] Objective: To investigate the influence of Tolterodine on bladder cell excitability and bladder contraction, in order to provide a reference for bladder hyperactivity disorder treatment. Methods: 80 cases of bladder hyperactivity disorder patients were divided into treatment group and control group, each of 40 cases. The treatment group was given Tolterodine for treatment, the control group was given Flavoxate Hydrochloride treatment. Results: Compared 24 h average frequency of urination and average single voided volume before and after treatment between the two groups were compared, the differences were statistically significant (P<0.05). After treatment, the average urination frequency of the treatment group was significantly less than that of the control group (t=9.363, P<0.05); the average single voided volume of the treatment group was significantly more than that of the control group (t=12.363, P<0.05). After treatment, the total effective rate was 95% in the treatment group, which was 75% in the control group (χ2=6.336, P<0.05). The overall incidence of adverse events included dry mouth, constipation, dysphoria between the two groups were compared, there were no statistically significant differences (P>0.05). Conclusion: Application of Tolterodine in the treatment of bladder hyperactivity disorder can significantly reduce excitability and contractile function of bladder cells, improve the therapeutic effect, and has no significant adverse reactions, which should be widely applied ......
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