非小细胞肺癌患者血清血管内皮生长因子受体2和内皮抑素与临床特征的相关性研究(1)
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[摘要] 目的：探究非小细胞肺癌患者外周血血管内皮生长因子受体2(vascular endothelial growth factor receptor 2，VEGFR-2)和内皮抑素(endostatin，ES)与临床特征的相关性及其意义。方法：选取2009年在上海市第六人民医院心胸外科接受手术治疗的38例非小细胞肺癌(non-small cell lung cancer，NSCLC)患者，用ELISA法检测其术前血清VEGFR-2、ES水平，分析二者相关性，并分析它们与年龄、性别、病理类型、肿瘤最大直径、肿瘤内血管密度(micro vessel density，MVD)、临床分期相关性及意义。结果：患者血清ES水平为(20.29±6.10)μg/L，VEGFR-2水平为(7.42±4.28)μg/L，ES表达水平与VEGFR-2表达水平无明显相关性(P>0.05)，ES与肺癌病灶内MVD呈直线负相关关系(r=-0.867，r2=0.752)，直线回归方程为Y=32.002-0.499X(μg/L)(P<0.001)；ES、VEGFR-2表达水平与其他临床特征无明显相关性(P>0.05)。结论：胸外科NSCLC患者外周血ES水平可能影响肺癌病灶内肿瘤内血管密度，从而影响肿瘤的生长，VEGFR-2、ES可能无法单独作为接受手术治疗NSCLC患者分期及预后判断的有效指标。
[关键词] 非小细胞肺癌；内皮生长因子受体2；内皮抑素
[中图分类号] R734.2 [文献标识码] A [文章编号] 1673-7210(2011)11(c)-024-03
Research of the correlations between serum levels of VEGFR-2, endostatin and clinical characters in patients with non-small cell lung cancer
YANG Yi1,2, ZHAO Tiancheng2, GAO Zongli2, WANG Xiuzhen1
1.Department of Pathology, Medical College of Soochow University, College of Basic Medical and Biological Sciences, Jiangsu Province, Soochow 215006, China; 2.Department of cardio thoracic Surgery, the 6th People's Hospital Afficicated to Shanghai Jiao Tong University, Shanghai 200233, China
[Abstract] Objective: To study the relationship between clinical significance and the serum levels of vascular endothelial growth factor receptor 2 (VEGFR-2), endostatin (ES) in patients with non-small cell lung cancer (NSCLC). Methods: The serum VEGFR-2, ES levels were detected by ELISA method in 38 patients with NSCLC in Shanghai 6th People's Hospital cardiothoracic surgery department in 2009. The correlations were analyzed among VEGFR-2, ES and the clinical characters, age, sex, pathology, diameter of tumor, clinical stage, micro vessel density (MVD) of tumor. Results: The serum level of ES [(20.29±6.10) μg/L] was uncorrelated with that of VEGFR-2 [(7.42±4.28) μg/L] (P>0.05); the serum level of ES was correlated with MVD of tumor (r=-0 ......
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