晚期肿瘤患者淋巴细胞亚群特点及临床意义(1)
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[摘要] 目的：通过观察晚期肿瘤患者外周血淋巴细胞亚群特点，探讨其免疫功能状况及临床意义。方法：应用流式细胞仪检测56例晚期肿瘤患者(肿瘤组)及42例健康体检者(健康组)外周血淋巴细胞亚群计数，并对其作比较。结果：肿瘤组较健康组T细胞亚群CD8+比值上升，CD4+、CD4+/CD8+比值下降，差值有统计学意义(P<0.05)，CD3+比值升高，差异无统计学意义(P>0.05)，B细胞亚群下降，差异有统计学意义(P<0.05)，NK比值下降，差异无统计学意义(P>0.05)。结论：晚期肿瘤患者的细胞免疫及体液免疫功能均低于健康人，其中体液免疫下降较明显，对临床应用提高免疫力药物也具有指导意义。
[关键词] 淋巴细胞亚群；免疫功能；流式细胞术
[中图分类号] R730.43 [文献标识码] B [文章编号] 1673-7210(2011)11(c)-094-02
Clinical characteristics and significance of lymphocyte subsets in patients with advanced cancer
ZHENG Shujun1, JIA Xihua2, WANG Yunliang2, GUO Jianmei2
1.Chengde Medical College, Hebei Province, Chengde 067000, China; 2.Department of Medical Oncology, the First Central Hospital of Baoding City, Hebei Province, Baoding 071000, China
[Abstract] Objective: To observe the clinical characteristics of lymphocyte subsets in the peripheral blood of patients with advanced cancer in order to evaluate immune function and clinical significance of lymphocyte subsets. Methods: Lymphocyte subsets counted in peripheral blood of 56 patients with advanced cancer and 42 cases of healthy people were compared by the flow cytometry. Results: CD8+ ratio of patients with advanced cancer was significantly higher than that of the healthy people, CD4+, CD4+/CD8+ ratio and B cell subgroup were significantly lower in cancer patients than that of the healthy people (all P<0.05). CD3+ ratio was higher in cancer patients and NK ratio was lower, but the differences were not statistically significant (P>0.05). Conclusion: Cellular immune function and humoral immune function of patients with advanced cancer are lower than that of healthy people, and the humoral immune function dropped significantly, this finding is instructive on how to improve the clinical application of immunity drugs.
[Key words] Lymphocyte subsets; Immune function; Flow cytometry
近年来，肿瘤发病率逐年增加，研究表明恶性肿瘤患者普遍存在免疫功能低下[1]，其发生是多因素、多阶段的，与机体免疫系统间的相互作用机制十分复杂[2]，本文运用流式细胞术的方法，检测并分析恶性肿瘤患者和健康人淋巴细胞亚群的特点，探讨肿瘤对患者免疫功能的影响，对临床具有指导作用。
1 资料与方法
1.1 一般资料
选取2009年1月～2010年12月我院健康体检者和肿瘤患者，总共98例。其中，健康体检者(健康组)42例，男24例，女18例；年龄45~64岁，平均53.2岁。肿瘤患者(肿瘤组)56例，均经过病理或细胞学确诊且临床分期为Ⅳ期；其中，男30例 ......
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