丙型肝炎患者生化变量与细胞因子间的相关性分析(1)
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[摘要] 目的：研究丙型肝炎病毒感染后血液生化变量与细胞因子重组人干扰素γ(interferon-γ，IFN-γ)、肿瘤坏死因子α(tumor necrosis factor，TNF-α)、重组人白介素10(interleukin-10，IL-10)之间的相关性。方法：以66例丙型肝炎患者为材料，利用统计学软件，分析丙型肝炎患者各生化指标之间及与3种细胞因子间的相关性。结果：①除球蛋白(GLO)与TNF-α在0.05置信水平上有较低相关性(r=-0.287，P=0.046)之外，各生化变量与各细胞因子之间无明显相关性。②各生化变量之间，丙氨酸氨基转换酶(ALT)与天门冬酸氨基转换酶(AST)有显著的相关性(r=0.869，P=0)，做除法后(ALT/AST)相关性基本被消除，各变量之间存在微弱互相关性。③除IFN-γ与TNF-α之间存在弱相关性(r=0.448，P=0.009)之外，各炎症细胞因子之间无明显相关性。结论：各生化指标之间、3种炎症细胞因子之间、各生化变量与3种炎症细胞因子间的相关性均较差。
[关键词] 丙型肝炎；细胞因子重组人干扰素γ；肿瘤坏死因子α；重组人白介素10
[中图分类号] R512.6+3 [文献标识码] A [文章编号] 1673-7210(2011)12(a)-020-03
Correlation between biochemical indicators and cytokines in hepatitis C patients
YOU Liyue1, CHI Shuping1, WANG Chen1, SUN Jie1, ZHOU Tingting2, CHEN Hongge1, ZHAO Qingguo1, CHENG Yun1*
1.Department of Pharmacy, the No.302 Hospital of PLA, Beijing 100039, China; 2.Institute of Basic Medical Sciences, Academy of Military Medical Science, Beijing 100850, China
[Abstract] Objective: To study the correlation between biochemical indicators and cytokines of interferon-γ (IFN-γ), tumor necrosis factor (TNF-α), interleukin-10 (IL-10) in hepatitis C patients. Methods: 66 patients with hepatitis C were selected as the material, the statistical software was used to analyze the correlation between biochemical indicators and the three cytokines in the 66 patients. Results: ①There was a lower correlation between GLO and TNF (r=-0.287, P=0.046), all biochemical indicators and the cytokines had no significant correlation. ②There was a significantly correlation between ALT and AST (r=0.869, P=0). ③There was a weak correlation between IFN-γ and TNF-α (r=0.448, P=0.009), there was no significant correlation among other cytokines. Conclusion: There are lower correlations not only in various biochemical indicators and in cytokines, but also between biochemical indicators and three cytokines.
[Key words] Hepatitis C; IFN-γ; TNF-α; IL-10
丙型病毒性肝炎是由丙型肝炎病毒(HCV)所引起，是危害人类健康的重要疾病之一，其中有很大一部分患者最终发展为肝硬化和肝癌[1]。长期以来，对于丙型肝炎慢性化和肝损伤的机制一直都在探讨之中[2]，在丙型肝炎的诊断和预后效果判断的过程中，肝生化指标的测定结果具有很重要的参考价值。此外，细胞因子重组人干扰素γ(interferon-γ ......
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