乙酰肝素酶、MMP-9在膀胱移行细胞癌侵袭转移中的表达相关性及临床意义(1)
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[摘要] 目的：检测乙酰肝素酶(heparanase，HPA)和基质金属蛋白酶-9(matrix metalloproteinase-9，MMP-9)在膀胱移行细胞癌、正常膀胱组织中的表达及相互关系，分析其与临床预后及浸润转移的关系。方法：应用免疫组化SP法检测92例膀胱移行细胞癌和10例正常膀胱组织中HPA、MMP-9的表达水平，分析两者的表达与临床病理指标的关系，建立Pearson等级相关分析。结果：HPA在膀胱移行细胞癌中的表达明显高于正常膀胱组织(77.2%，0；P<0.05)，HPA阳性表达与周围组织浸润(χ2=11.918，P<0.05)、淋巴结转移(χ2=5.380，P<0.05)有关，与性别、年龄、组织学分级及1年生存率无关(P>0.05)；膀胱移行细胞癌组织中MMP-9表达明显高于正常膀胱组织(70.7%，20.0%；P<0.05)，且MMP-9阳性表达与周围组织浸润(χ2=4.329，P<0.05)、远处转移(χ2=10.301，P<0.05)有关，与性别、年龄、组织学分级及1年生存率无关(P>0.05)。HPA与MMP-9有较高的共同阳性表达率(P=0.018)。HPA和MMP-9表达呈正相关(r=0.729，P<0.05)， 其共同表达率与肿瘤对周围脏器浸润和淋巴结转移有相关性(P<0.05)。结论：HPA、MMP-9在膀胱移行细胞癌组织中的表达可能与膀胱移行细胞癌浸润、转移相关，可作为新的膀胱移行细胞癌标记物用于联合检测，具有重要的临床意义。
[关键词] 乙酰肝素酶；基质金属蛋白酶-9；膀胱移行细胞癌
[中图分类号] R737.14 [文献标识码] A [文章编号] 1673-7210(2012)01(a)-022-03
HPA and MMP-9 in the expression of invasion and metastasis of bladder transitional cell carcinoma and clinical significanc
CHEN Fang1, LI Li2
1.Department of Nephrology, the Huaihe Hospital of He′nan University, He′nan Province, Kaifeng 475001, China;2.College of Nursing, He'nan University, He′nan Province, Kaifeng 475001, China
[Abstract] Objective: To investigate the expression of heparanase and matrix metalloproteinase-9 (MMP-9), and their correlations with the metastasis and prognosis of bladder transitional cell carcinoma. Methods: Immunohistochemical staining (SP method) was used to measure HPA and MMP-9 expression in 92 cases of bladder transitional cell carcinoma and 10 cases of normal pancreas. Correlations of the expression of HPA and MMP-9 to clinicopathologic features were analyzed. Pearson regress ionmodel was used to analyze. Results: The expression of HPA in bladder transitional cell carcinoma was significantly higher than that in normal bladders (77 ......
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