紫杉醇脂质体-卡铂新辅助化疗治疗中晚期宫颈癌临床观察(1)
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[摘要] 目的：探讨紫杉醇脂质体-卡铂新辅助化疗治疗中晚期宫颈癌的临床疗效。方法：52例Ⅱb、Ⅲ期中晚期宫颈癌患者分为实验组(n=24)和对照组(n=28)，前者用紫杉醇脂质体-卡铂新辅助化疗，后者用紫杉醇-卡铂化疗，观察两组的近期疗效以及毒副反应。结果：实验组和对照组近期疗效有效率分别为75.00%和57.14%，两组比较差异无统计学意义(P>0.05)。实验组和对照组均发生了白细胞减少、恶心呕吐、谷丙转氨酶升高、呼吸困难、肌肉酸痛等不良反应，但实验组呼吸困难、肌肉酸痛的发生率明显低于对照组，差异有统计学意义(P<0.05)。结论：紫杉醇脂质体-卡铂新辅助化疗具有较好的疗效，毒副反应也较紫杉醇-卡铂化疗方案明显减少，耐受性好。
[关键词] 紫杉醇脂质体；紫杉醇；宫颈癌
[中图分类号] R737.33 [文献标识码] A [文章编号] 1673-7210(2012)01(a)-049-03
Clinical effects of Paclitaxel Liposome-Oxaliplatin Neoadjuvant chemotherapy on advanced cervical cancer
YE Bing, SUN Zhengping, LU Youguo
Department of Oncology, Xinhua Hospital of Huainan City, Anhui Province, Huainan 232052, China
[Abstract] Objective: To investigate the clinical effects of the Paclitaxel Liposome-Carboplatin Neoadjuvant chemotherapy on advanced cervical cancer. Methods: 52 patients with advanced cervical cancer at stage Ⅱb and Ⅲ were divided into experiment group (24 patients) and control group (28 patients), and the patients in the experiment group were treated with Paclitaxel Liposome-Oxaliplatin Neoadjuvant chemotherapy, and those in control group were treated with Paclitaxel-Oxaliplatin chemotherapy. Their short-term clinical efficacy and toxicity were observed and compared. Results: The rates of clinical effects were 75.00% in the experiment group and 57.14% in the control group with no statistically significant (P>0.05). The adverse reactions including leukopenia, nausea, vomiting, elevating of alanine aminotransferase, breathing difficulties and muscle soreness were observed in the experiment group and control group, the rates of breathing difficulties, muscle soreness were significantly higher in the experiment group than those in the control group (P<0.05). Conclusion: The Neoadjuvant interventional chemotherapy with Paclitaxel Liposome-Oxaliplatin was an effective method to advanced cervical cancer, which can decrease the allergic reactions and should be suggested in clinical experiences.
[Key words] Paclitaxel Liposome; Paclitaxel; Cervical cancer
宫颈癌(cervical cancer)是女性最常见的生殖系统恶性肿瘤 ......
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