当前位置: 首页 > 期刊 > 《医药产业资讯》 > 2012年第2期 > 正文
编号:12176899
两种方案治疗晚期胃癌的临床对照研究(3)
http://www.100md.com 2012年1月15日 赖邻宁 马小南 杜敏 祝艳华 杜华昆
第1页

    参见附件。

     总之,伊立替康联合S-1治疗晚期胃癌疗效肯定,应用方便,耐受性较好。可做为一线化疗方案。也是化疗治疗失败后的二线选择。对不能耐受两药联合化疗的初治病例,单药S-1也值得推荐。由于样本量较小,还需要进一步扩大临床研究,为临床实践提供更有力的依据。

    [参考文献]

    [1] Jemal A,Segel R,Ward E,et al,Cancer statistics [J]. CA Cancer J Clin,2009,59(4):225-249.

    [2] Pozzo C,Barone C,Szanto J,et al. Irinotecan in combination with 5-fluorouracil and folinic acid or with cisplatin in patients with advanced gastric or esophageal-gastric junction adenocarcinoma:results of a randomized phase Ⅱ study [J]. Ann Oncol,2004,15(12):1773-1781.

    [3] 刘荫华,刘倩.客观解读RECIST(修订版)的临床评价意义 [J]. 中国实用外科杂志,2010,1:31-33.

    [4] Glimelius B, Ekstrom K, Hotfmann K, et al. Initial or delayed chemotherapy with best supportive care in advanced gastric cancer [J]. Ann Oncol,1994,5(2):189-190.

    [5] Ohtsu A, Shimada Y, Shirao K, et al. Randomized phase Ⅲ trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer [J]. The Japan Clinical Oncology Group Study(JCOG9205),J Clin Oncol,2003,21(1):54-59.

    [6] Kato T, Shimamoto Y, Uchida J, et al. Possible regulation of 5-fluorouracil-induced neuro- and oral toxicities by two biochemical modulators consisting of S-1,a new oral formulation of 5-fluorouracil [J]. Anticancer Res,2001,21(3B):1705-1712.

    [7] Robben NC, Pippas AW, Moore JO. The syndrome of 5-fluorouracil cardiotoxicity [J] ......

您现在查看是摘要介绍页,详见PDF附件(2989kb)