类风湿关节炎诊治中的血脂变化研究(1)
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[摘要] 目的 观察血脂变化在类风湿关节炎诊治中的临床价值。 方法 86例类风湿关节炎(RA)患者，通过抗风湿药物和小剂量激素治疗1年后，对治疗前后的血沉、C反应蛋白、类风湿因子、总胆固醇、三酰甘油、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇进行检测，分析血脂变化在诊治中的价值。 结果 类风湿关节炎患者治疗后血沉、C反应蛋白、总胆固醇都明显低于治疗前(P < 0.05)，而高密度脂蛋白胆固醇较治疗前有明显的升高(P < 0.05)。但治疗前后低密度脂蛋白胆固醇和三酰甘油变化不明显(P > 0.05)。血沉与高密度脂蛋白胆固醇呈负相关(P < 0.05)，C反应蛋白、类风湿因子与高密度脂蛋白胆固醇未出现相关性(P > 0.05)。 结论 血脂变化在类风湿关节炎的诊治中具有重要价值，类风湿关节炎与脂代谢、炎症反应有着密切的关系。
[关键词] 类风湿；关节炎；血脂
[中图分类号] R593.22 [文献标识码] A [文章编号] 1673-7210(2012)01(b)-057-02
Research on blood lipid change of rheumatoid arthritis
CHEN Xiaoming1 YOU Yunhui2 LUO Hui2 PENG Yangang1
1.Department of Rheumatism, Shaoyang City Central Hospital, Hu′nan Province, Shaoyang 422000, China; 2.Department of Rheumatism, Xiangya Hospital of Cental South University, Hu′nan Province, Changsha 410008, China
[Abstract] Objective To observe the clinical value of blood lipid change in diagnosis and treatment of rheumatoid arthritis. Methods 86 patients who were diagnosed as rheumatoid arthritis received anti-rheumatoid drug and small doses of hormone treatment, after 1 year, ESR, CRP, rheumatoid factor, TC, TG, LDL-C and HDL-C were detected before and after treatment, blood lipid change of patients were analyzed for the value of diagnosis and treatment. Results After treatment, the patients with rheumatoid arthritis were significantly lower than before treatment on ESR, CRP, TC (P < 0.05), but HDL-C was significantly rise than before treatment (P < 0.05), LDL-C and TG had no significantly change than before treatment (P > 0.05). ESR and HDL-C had the negative correlation (P < 0.05). CRP, rheumatoid factor and HDL-C did not appear correlation (P > 0.05). Conclusion Blood lipid change has important value in the diagnosis and treatment of rheumatoid arthritis, rheumatoid arthritis has a close relationship with lipid metabolism and inflammatory responses.
[Key words] Rheumatoid; Arthritis; Blood lipid
类风湿关节炎(RA)是全身炎症性病变，机体免疫系统对此将做出反应，随着炎症因子的作用一起，对体内的物质代谢产生反应，特别是机体需要的营养物质，比如蛋白质和脂肪，蛋白和脂肪代谢的紊乱，使得类风湿关节炎患者心血管系统疾病的发病率骤然升高[1-2]。为了了解血脂变化在类风湿关节炎诊治中的价值，至此本文将分析类风湿关节炎患者血脂在治疗过程中的变化，以期通过分析得出血脂在类风湿关节炎诊治中的意义。
1 资料与方法
1.1 一般资料
本文筛选2009年1月~2010年12月在本院风湿免疫科就诊的类风湿关节炎患者86例，患者均按照美国风湿病学会修订的类风湿关节炎分类标准(1987版)进行诊断[3] ......
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