连续气道正压通气对阻塞性睡眠呼吸暂停患者血流动力学的影响(1)
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[摘要] 目的 利用无创血流动力监测系统评估阻塞性睡眠呼吸暂停综合征(OSAS)患者血流动力学变化；评估连续气道正压通气(CPAP)对患者血流动力学的作用。 方法 选择OSAS患者65例和健康对照组35例，使用无创胸电生物阻抗法分别测定所有受试者血流动力学参数。对OSAS患者使用CPAP治疗6个月和9个月后再次评估其血流动力学参数。 结果 与对照组相比，OSAS组患者心脏指数[(3.8±0.8)L/(min·m2) vs(3.9±0.6)L/(min·m2)]，心搏指数[(48.6±17.5)mL/m2 vs(55.4±15.9)mL/m2]和左室射血时间[(280.6±103.2)ms vs(310.3±98.9)ms]值均低于对照组(均P < 0.05)，其平均动脉压[(100.1±20.5)mm Hg vs(90.5±15.6)mm Hg(1 mm Hg=0.133 kPa)]、系统血管阻力[(1 259.3±258.8)Dyns/cm5 vs(950.9±110.7)Dyns/cm5]、系统血管阻力指数[(1 982.8±481.7)Dyns m2/cm5 vs(1 683.5±301.9)Dyns m2/cm5]均高于对照组(均P < 0.05)。与治疗前相比较，经CPAP治疗后6个月后，OSAS系统血管阻力和系统血管阻力指数下降(P < 0.05)；经CPAP治疗9个月后，OSAS患者血流动力学监测测参数均改善(均P < 0.05)。 结论 OSAS患者早期已存在全身血流动力学异常，与低氧血症密切相关；CPAP能够改善患者血流动力学监测指标。
[关键词] 睡眠呼吸暂停综合征；血流动力学；连续气道正压通气
[中图分类号] R563.9 [文献标识码] A [文章编号] 1673-7210(2012)01(c)-0054-03
Influence of continuous positive airway pressure on hemodynamics of patients with obstructive sleep apnea
WANG Hejin YANG Shukun▲ SUN Yanfen XU Fuqin
Longgang People's Hospital, Guangdong Province, Shenzhen 518172, China
[Abstract] Objective Through the non-invasive hemodynamic monitoring system, to evaluate the hemodynamics changes of patients with obstructive sleep apnea syndrome (OSAS) and to evaluate the influence of continuous positive airway pressure (CPAP) on the hemodynamics of patients. Methods 65 patients with OSAS and 35 healthy person were selected. The non-invasive thoracic electrical bio-impedance method was used to measure the hemodynamic parameters of all the subjects. The hemodynamic parameters of patients with OSAS were reevaluated 6 and 9 months after CPAP treatment. Results Compared with patients of the control group, those of the OSAS group were significantly lower in the cardiac index [(3.8±0.8)L/(min·m2) vs(3.9±0.6)L/(min·m2)], cardiac index [(48.6±17.5)mL/m2 vs(55 ......
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