厄贝沙坦佐治高血压伴心力衰竭的疗效及对血清中超敏C反应蛋白和脑利钠肽的影响(1)
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[摘要] 目的 探讨厄贝沙坦佐治高血压伴心力衰竭的疗效及对血清中超敏C反应蛋白(hs-CRP)和脑利钠肽(BNP)的影响，探讨其临床意义。 方法 选取126例确诊为高血压伴心力衰竭的患者，将其随机分为观察组(63例)与对照组(63例)，对照组应用常规治疗，观察组在常规治疗的基础上加用厄贝沙坦进行治疗。观察两组治疗前后的疗效及血清中hs-CRP和BNP的变化。 结果 观察组治疗后总有效率和6分钟步行实验均明显优于对照组(P < 0.05)。观察组与对照组治疗后血清中hs-CRP和BNP的含量均明显低于治疗前(P < 0.05)，但观察组治疗前后血清中hs-CRP和BNP的下降值明显高于对照组(P < 0.05)。 结论 厄贝沙坦佐治高血压伴心力衰竭的疗效明显，且能有效下调血清中hs-CRP和BNP的含量，临床中可以积极应用。
[关键词] 厄贝沙坦；心力衰竭；超敏C反应蛋白；脑利钠肽；酶联免疫吸附实验
[中图分类号] R541.61 [文献标识码] A [文章编号] 1673-7210(2012)02(c)-0053-03
The efficacy of Irbesartan in treatment of hypertension patients with heart failure and the effect of serum hs-CRP and BNP
LU Sheng
Department of Cardiology, the 3rd People's Hospital of Huaihua City, Hu'nan Province, Huaihua 418000, China
[Abstract] Objective To observe the curative effect, hs-CRP and BNP change in hypertension patients with heart failure by Irbesartan, and to explore clinical significance. Methods 126 hypertension patients with heart failure were divided into observation group (63 cases) and control group (63 cases). The control group (63 cases) was treated by routine treatment, the observation group (63 cases) was treated by routine treatment and Irbesartan. The efficacy, serum hs-CRP and BNP before and after treatment were observed in the two groups. Results The efficacy and 6-minute walk test change were obviously higher in the observation group than those in the control group (P < 0.05). The expressions of hs-CRP and BNP obviously decreased after treatment in the two groups (P < 0.05). But the decrease values of hs-CRP and BNP were higher in the observation group than those in the control group(P < 0.05). Conclusion Irbesartan can improve the curative effect, decrease the expressions of hs-CRP and BNP in hypertension patients with heart failure, it is worthy of being recommended in clinical treatment.
[Key words] Irbesartan; Heart failure; hs-CRP; BNP; ELISA
高血压伴慢性心力衰竭患者发病时间长，由于心肌梗死、心肌纤维化、心肌冬眠、心肌硬化等病变，进而引起进行性心肌肥大、心功能减退、心律失常及猝死等。疾病发展过程中，血清中相关细胞因子会有明显改变。脑利钠肽(BNP)是心肌细胞分泌的一种激素，具有拮抗神经内分泌系统的激活、扩张血管和利钠、利尿的作用，在心力衰竭患者血清中的表达升高[1]。超敏C反应蛋白(hs-CRP)是人类肝细胞合成的急性时相蛋白，当机体受到炎症感染或组织损伤时 ......
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