拓扑异构酶Ⅱα和尿激酶型纤溶酶原激活物在乳腺癌中的表达及其临床意义(1)
 |
| 第1页 |
参见附件。
[摘要] 目的 研究乳腺癌组织中拓扑异构酶Ⅱα(TOPOⅡα)和尿激酶型纤溶酶原激活物(UPA)表达的相关性及临床意义。 方法 采用免疫组织化学SP法，检测69例乳腺癌组织中TOPOⅡα及UPA的表达情况。 结果 乳腺癌中TOPOⅡα的阳性率为42.03%(29/69)，UPA的阳性率为59.42%(41/69)，二者的表达成高度正相关(r = 0.9984)。TOPOⅡα在无淋巴结转移组的阳性表达率明显高于有淋巴结转移组(P < 0.05)，UPA在无淋巴结转移组的阳性表达率也明显高于有淋巴结转移组(P < 0.05)，二者与乳腺癌的年龄、部位无明显相关性。 结论 TOPOⅡα和UPA在乳腺癌中表达与淋巴结转移有相关性。检测TOPOⅡα和UPA对临床选择治疗方法有指导意义。
[关键词] 乳腺癌；拓扑异构酶Ⅱα；尿激酶型纤溶酶原激活物；免疫组织化学
[中图分类号] R737.9 [文献标识码] A [文章编号] 1673-7210(2012)04(a)-0033-02
Expression and clinical significance of TOPOⅡα and UPA in breast cancer
LIU Weijie1 LI Junying1 ZHANG Xiaoli2 REN Junxu2 MA Yanna2
1.Department of Obstetrics and Gynecology, the Fifth Hospital of Zhangjiakou City, Hebei Province, Zhangjiakou 075000, China; 2.Hebei North University, Hebei Province, Zhangjiakou 075000, China
[Abstract] Objective To study the expression and clinical significance of topoisomerseⅡα (TOPOⅡα) and urokinase type plasmivnogen activator (UPA) in breast cancer. Methods The expressions of TOPOⅡα and UPA were examined with streptavidin-perosidase immunohistochemistry method in 69 cases of breast cancer. Results The positive rates of TOPOⅡα and UPA were 42.03% (29/69) and 59.42% (41/69) in breast cancer respectively. TOPOⅡα had a high relation with UPA in breast cancer (r = 0.9984). The positive rates of TOPOⅡα in non-lymph metastasis group was higher than that in lymph metastasis (P < 0.05). The positive rates of UPA in non-lymph metastasis group was higher than that in lymph metastasis too (P < 0.05), but its pathological type and breast cancer pathological type relevance was not obvious (P > 0.05). Conclusion The expression of TOPOⅡα and UPA have relation with breast cancer metastasis. It is directing significance of detection of TOPOⅡα and UPA on clinical selection treatment.
[Key words] Breast cancer; TopoisomerseⅡα; Urokinase type plasmivnogen activator; Immunohistochemistry
近年来乳腺癌发病率有明显增高的趋势，其发病机制和化学治疗措施的选择是人们研究的热点问题之一。拓扑异构酶Ⅱα(TOPOⅡα)和尿激酶型纤溶酶原激活物(UPA)在肿瘤中的表达与化学药物的选择密切相关[1-2]，为了提高化学治疗效果，人们对它们的研究非常重视。TOPOⅡα和UPA在肿瘤转移中的作用，对防治乳癌也有重要意义，笔者采用敏感性很高的免疫组化SP法检测69例乳癌中TOPOⅡα和UPA的表达率 ......
您现在查看是摘要介绍页，详见PDF附件(1738kb)。