乙肝携带产妇血清、乳汁及新生儿血清中HBVDNA载量的关系探讨(1)
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[摘要] 目的 探讨乙型肝炎病毒携带产妇血清及乳汁中HBV DNA载量与新生儿血清中HBV DNA载量的关系，以指导临床采取正确的孕期处理和母乳喂养措施。 方法 选择乙型肝炎病毒携带产妇293例，采用荧光定量PCR技术测定产妇血清、母乳和新生儿血清HBV DNA载量，并将产妇血清HBV DNA载量分为血清阴性组(HBV DNA<103 copies/mL)、血清低拷贝组(103 copies/mL≤HBV DNA≤106 copies/mL)和血清高拷贝组(HBV DNA>106copies/mL)，并按标本类型和HBV DNA水平进行比较。 结果 293例HBV感染产妇中，HBV DNA阴性组、低拷贝组和高拷贝组分别占50.2%、21.8%和28.0%。血清HBV DNA阴性组产妇乳汁中HBV DNA检出率为0。而血清低拷贝组和高拷贝组产妇乳汁HBV DNA的阳性检出率分别为12.5%和76.8%，前者明显低于后者(P < 0.01)。而血清HBV DNA阴性组、低拷贝组和高拷贝组之间新生儿血清HBV DNA阳性率差异均无统计学意义(P > 0.05)。 结论 产妇血清中HBV DNA载量与乳汁中HBV DNA阳性率呈正相关。产妇血清HBV DNA载量与胎儿宫内感染无明显相关性。
[关键词] 乙型肝炎病毒；乳汁；血清；新生儿；乙肝DNA
[中图分类号] R512.6+2 [文献标识码] B [文章编号] 1673-7210(2012)07(c)-0096-02
The correlation between HBV DNA in serum, breast milk of HBV-carring parturient women and the one in serum of newborn
XIA Wei1 CHEN Fang2
1.Department of Laboratory, the People′s Hospital of Chongqing Dadukou District, Chongqing 400084, China; 2.Department of Laboratory, the Third People′s Hospital of Zigong City, Sichuan Province, Zigong 643000, China
[Abstract] Objective To discuss the correlation between HBV DNA in serum, breast milk of HBV-carring parturient women and the one in serum of newborn for supplying a correct clinic guidance of pregnancy management and breast feeding measures. Methods HBV DNA in serum, breast milk of HBV-carring parturient women (n=293) and serum of newborn were detected by fluorescence quantitative PCR. 293 cases of parturient women were divided into three groups according to HBV DNA load: serum negative group (HBV DNA<103 copies/mL), serum low copies group (103 copies/mL≤HBV DNA≤106 copies/mL) and serum high copies group (HBV DNA>106copies/mL) ......
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