基质金属蛋白酶1及其抑制剂在舌癌浸润性转移中的作用(1)
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[摘要] 目的 检测舌癌黏膜固有层组织中基质金属蛋白酶-1(MMP-1)、基质金属蛋白酶抑制剂-1(TIMP-1)的表达，揭示它们在舌癌浸润和转移中的作用。 方法 应用ABC免疫组织化学染色方法分别检测舌癌标本及正常组织各取材部位中MMP-1、TIMP-1的免疫学定位及表达情况。 结果 舌癌组织的MMP-1和TIMP-1的阳性表达率与对照组相比，差异有高度统计学意义(P < 0.01)；舌癌组织中的MMP-1和TIMP-1的表达与舌癌大小无关(P > 0.05)，而与舌癌分化程度、有无转移、病理分级等具有差异(P < 0.05或P < 0.01)。 结论 MMP-1和TIMP-1在舌癌黏膜固有层组织中的表达关系，有助于判断舌癌的侵袭和转移及病理分期。
[关键词] 基质金属蛋白酶-1；基质金属蛋白酶抑制剂-1；舌癌
[中图分类号] R735.3 [文献标识码] A [文章编号] 1673-7210(2012)08(c)-0014-03
Effect of MMP-1 and TIMP-1 in tongue cancer with invasion and metastasis ZHANG Peng JI Liang SHEN Lei LI Jingping WANG Yan ZHANG Cuixiang SHA Feng
Department of Anatomy, Qiqihar Medical University, Heilongjiang Province, Qigihar 161006, China
[Abstract] Objective To detect the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in mucosa lamina propria tissue of tongue cancer, in order to reveal the role of MMP-1 and TIMP-1 in the invasion and metastasis of tongue cancer. Methods The immunological localization and expression of MMP-1 and TIMP-1 in tongue cancer specimens and normal tissues were detected by immunohistochemical staining methods (ABC method). Results Positive expression rate of MMP-1 and TIMP-1 between tongue cancer tissues and normal tissues was significantly different (P < 0.01). The expression of TIMP-1 and MMP-1 in tongue cancer tissues had no relationship with the size of tongue cancer (P > 0.05), but it had significantly differences compared with differentiation degree, metastasis and pathological grade of tongue cancer (P < 0.05 or P < 0.01). Conclusion The expression of MMP-1 and TIMP-1 in mucosa lamina propria tissue of tongue cancer can contribute to judge the invasion, metastasis and pathological grade of tongue cancer ......
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