重组葡激酶与尿激酶治疗急性心肌梗死的疗效观察(1)
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[摘要] 目的 观察重组葡激酶(r-Sak)与尿激酶(UK)治疗急性心肌梗死(AMI)的疗效。 方法 选择我院2010年1月～2012年1月接受治疗的200例AMI患者，将其随机分为UK组和r-Sak组，各100例。r-Sak组给予0.9%生理盐水100 mL + r-Sak 10 mg，UK组给予UK 150万U + 0.9%氯化钠注射液100 mL。观察并记录两组患者临床症状缓解情况，判断两组治疗效果。 结果 r-Sak组胸痛症状缓解率、再通率、总有效率均高于UK组，差异均有统计学意义(均P < 0.05)；r-Sak组死亡率、梗死后心绞痛发生率、心力衰竭发生率、心律失常发生率、平均住院天数、并发症发生率均低于UK组，差异均有统计学意义(均P < 0.05)。 结论 r-Sak治疗AMI的效果优于UK，再开通率高，复合临床事件发生率低，效果肯定，值得推广。
[关键词] 重组葡激酶；尿激酶；急性心肌梗死；静脉溶栓
[中图分类号] R542.22 [文献标识码] A [文章编号] 1673-7210(2012)08(c)-0085-03
The curative effects of urokinase and recombinant staphylokinase in the treatment of acute myocardial infarction
ZHOU Baihua1 TONG Qiaoxia2
1.Department of Cardiology, the People's Hospital of Dong′an County, Hu′nan Province, Dong′an 425900, China; 2.the Affiliated Union Hospital of Tongji Medical College of Huazhong University of Science and Technology, Hubei Province, Wuhan 430022, China
[Abstract] Objective To observe the curative effects of urokinase (UK) and recombinant staphylokinase (r-Sak) in the treatment of acute myocardial infarction (AMI). Methods 200 cases with AMI in our hospital from January 2010 to January 2012 were chosen and randomly divided into UK group and r-Sak group, each of 100 cases, r-Sak group was given 0.9% saline 100 mL + r-Sak 10 mg, UK group was given UK 1.5 million U + 0.9% sodium chloride injection 100 mL. The clinical symptoms of patients in two groups were observated and recorded, and the therapeutic effect were judged. Results Chest pain relief, the recanalization, the total effective rate rate in r-Sak group were higher than those in the UK group, the differences were statistically significant (P < 0 ......
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