锝99—甲氧基乙腈亲肿瘤显像预测非小细胞肺癌化疗效果的临床研究(1)
[摘要] 目的 探讨锝99-甲氧基乙腈(99Tcm-MIBI)亲肿瘤显像对非小细胞肺癌化疗效果的预测价值。 方法 收集2013～2015年云南省肿瘤医院不能手术的非小细胞肺癌患者40例，其中鳞癌23例，腺癌14例，大细胞癌3例，患者在化疗前，静脉注射7.40×108 Bq 99Tcm-MIBI后分别于30 min，2 h行SPECT动态扫描，计算早期相、延迟相肿瘤组织与对侧正常肺组织的放射活性比(T/Ne、T/Nd)并计算出滞留指数(RI)，根据胸部CT的实体瘤的疗效评价标准，将患者分为化疗有效组(21例)和无效组(19例)。 结果 化疗有效组T/Ne(2.1837±0.6694)、T/Nd(2.5321±0.8478)均高于化疗无效组T/Ne(1.6438±0.5575)、T/Nd(1.7652±0.6352)，差异有统计学意义(P < 0.05)；RI化疗有效组(0.1578±0.1677)与无效组(0.0665±0.1219)比较，差异无统计学意义(P > 0.05)。 结论 99Tcm-MIBI显像的T/Ne、T/Nd、RI有助于预测非小细胞肺癌化疗的疗效。
[关键词] 非小细胞肺癌；锝99-甲氧基乙腈；化疗
[中图分类号] R734.2 [文献标识码] A [文章编号] 1673-7210(2016)04(a)-0112-03
Department of Nuclear Medicine， Yunnan Provincial Tumor Hospital the Third Affiliated Hospital of Kunming Medical University， Yunnan Province， Kunming 650118， China
[Abstract] Objective To discuss the effect of 99Tcm-MIBI tumor seeking imagining predicting non-small cell lung cancer chemotherapeutic. Methods From 2013 to 2015， in Yunnan Provincial Tumor Hospital， 40 patients with inoperable non-small cell lung cancer were collected， including 23 cases of squamous carcinoma， 14 cases of adenocarcinoma and 3 cases of large cell carcinoma. Before chemotherapy， the patients were given intravenous injection of 7.40×108 Bq 99Tcm-MIBI. At the time points of 30 min and 2 h， SPECT dynamic scanning was carried out respectively. The radioactivity ratio of early， delay tumor tissue and the normal lung tissue in the opposite side (T/Ne， T/Nd) were calculated， and then the retention index (RI) was calculated. According to the evaluation criteria in solid tumor of chest CT， the patients were divided into chemotherapy effect group (21 cases) and chemotherapy ineffect group (19 cases). Result T/Ne (2.1837±0.6694)， T/Nd (2.5321±0.8478) of chemotherapy effect group were higher than T/Ne (1.6438±0.5575)， T/Nd (1.7652±0.6352) of the chemotherapy ineffect group， the differences were statistically significant (P < 0.05)； RI of the chemotherapy effect group (0.1578±0.1677) was compared with chemotherapy ineffect group (0.0665±0.1219)， the difference was not statistically significant (P > 0.05). Conclusion T/Ne， T/Nd and RI of 99Tcm-MIBI imagining are helpful to predict the curative effect of chemotherapy on treating non-small cell lung cancer.
[Key words] Non-small cell lung cancer； 99mTc-MIBI； Chemotherapy云南是肺癌的高发区，且属于贫困落后区域，许多患者由于经济困难，而导致治疗延误，往往病情发展到晚期无法手术治疗才入院就诊[1]。此时化疗方案就显得尤为重要，但由于患者的个体差异，无法做到化疗个体化，对化疗无效的患者接受化疗后不但无益，相反会延误治疗时间，降低机体免疫力，从而降低生存率[2]。故如何预测肺癌化疗效果具有重要的临床意义。, 百拇医药(刘超 陆建梅 李骏鹏 刘鹏杰 贾莉 邓智勇)
[关键词] 非小细胞肺癌；锝99-甲氧基乙腈；化疗
[中图分类号] R734.2 [文献标识码] A [文章编号] 1673-7210(2016)04(a)-0112-03
Department of Nuclear Medicine， Yunnan Provincial Tumor Hospital the Third Affiliated Hospital of Kunming Medical University， Yunnan Province， Kunming 650118， China
[Abstract] Objective To discuss the effect of 99Tcm-MIBI tumor seeking imagining predicting non-small cell lung cancer chemotherapeutic. Methods From 2013 to 2015， in Yunnan Provincial Tumor Hospital， 40 patients with inoperable non-small cell lung cancer were collected， including 23 cases of squamous carcinoma， 14 cases of adenocarcinoma and 3 cases of large cell carcinoma. Before chemotherapy， the patients were given intravenous injection of 7.40×108 Bq 99Tcm-MIBI. At the time points of 30 min and 2 h， SPECT dynamic scanning was carried out respectively. The radioactivity ratio of early， delay tumor tissue and the normal lung tissue in the opposite side (T/Ne， T/Nd) were calculated， and then the retention index (RI) was calculated. According to the evaluation criteria in solid tumor of chest CT， the patients were divided into chemotherapy effect group (21 cases) and chemotherapy ineffect group (19 cases). Result T/Ne (2.1837±0.6694)， T/Nd (2.5321±0.8478) of chemotherapy effect group were higher than T/Ne (1.6438±0.5575)， T/Nd (1.7652±0.6352) of the chemotherapy ineffect group， the differences were statistically significant (P < 0.05)； RI of the chemotherapy effect group (0.1578±0.1677) was compared with chemotherapy ineffect group (0.0665±0.1219)， the difference was not statistically significant (P > 0.05). Conclusion T/Ne， T/Nd and RI of 99Tcm-MIBI imagining are helpful to predict the curative effect of chemotherapy on treating non-small cell lung cancer.
[Key words] Non-small cell lung cancer； 99mTc-MIBI； Chemotherapy云南是肺癌的高发区，且属于贫困落后区域，许多患者由于经济困难，而导致治疗延误，往往病情发展到晚期无法手术治疗才入院就诊[1]。此时化疗方案就显得尤为重要，但由于患者的个体差异，无法做到化疗个体化，对化疗无效的患者接受化疗后不但无益，相反会延误治疗时间，降低机体免疫力，从而降低生存率[2]。故如何预测肺癌化疗效果具有重要的临床意义。, 百拇医药(刘超 陆建梅 李骏鹏 刘鹏杰 贾莉 邓智勇)