系统护理干预对新辅助化疗治疗骨肉瘤患者毒副作用的影响(1)
[摘要] 目的 探究与分析系统护理干预对新辅助化疗治疗骨肉瘤患者毒副作用的影响。 方法 选取2014年1月～2015年1月哈尔滨医科大学附属第一医院收治的接受新辅助化疗的骨肉瘤患者90例，采取随机数字表法将其分为常规护理组与系统护理干预组，每组各45例。比较两组患者随访1年生存率、肿瘤复发率、肿瘤细胞坏死率、化疗期间并发症发生率、护理满意度及生活质量。 结果 常规护理组与系统护理干预组随访1年生存率、肿瘤复发率及肿瘤细胞坏死率比较，差异均无统计学意义(P > 0.05)。系统护理干预组与常规护理组比较，恶心呕吐、口腔黏膜炎、肾功能损害、感染、病理性骨折、血肿、疼痛发生率均较低，差异均有统计学意义(P < 0.05)。常规护理组的护理满意度为75.56%，系统护理干预组的护理满意度为93.33%，系统护理干预组的护理满意度明显高于常规护理组，差异有统计学意义(P < 0.05)。系统护理干预组躯体功能、角色功能、认知功能、情绪功能及社会功能评分明显低于常规护理组，差异均有统计学意义(P < 0.05)。 结论 将系统护理干预应用于新辅助化疗治疗的骨肉瘤患者中，对患者术后生成率及复发率不会造成影响，且可降低并发症发生率，提高生活质量。
[关键词] 系统护理干预；新辅助化疗；骨肉瘤；毒副作用
[中图分类号] R595.2 [文献标识码] A [文章编号] 1673-7210(2016)07(a)-0160-04
[Abstract] Objective To explore and analyze the toxic and side effect of systematic nursing intervention on neoadjuvant chemotherapy for patients with osteosarcoma. Methods Ninety patients with osteosarcoma treated with neoadjuvant chemotherapy in the First Affiliated Hospital of Harbin Medical University from January 2014 to January 2015 were selected. All the patients were divided into two groups according to a random number table， the conventional nursing care group and systemic nursing intervention group， 45 cases in each group. The postoperative survival rate， tumor recurrence rate， tumor cell necrosis rate 1 year postoperative follow-up， nursing satisfaction and life quality of patients in the two groups during the period of chemotherapy were compared. Results The survival rate， tumor recurrence rate and tumor cell death rate of patients in the two group1 year postoperative follow-up had no statistically significant difference (P > 0.05). The nausea and vomiting， oral mucositis， liver and kidney impairment， pathological fracture， hematoma， infection rate， incidence of pain of the systemic nursing intervention group were lower than those of the conventional nursing group， the differences were statistically significant (P < 0.05). The nursing satisfaction rate of the conventional nursing group was 75.56%， while the systemic nursing intervention group was 93.33%， the nursing satisfaction of the systemic nursing intervention group was obviously higher than that of the conventional nursing group， the differences were statistically significant (P < 0.05). The physical function， role function， cognitive function， emotional function and social function scores of the systemic nursing intervention group were lower than those of the conventional nursing care group， the differences were statistically significant (P < 0.05). Conclusion The systemic nursing intervention will not affect generation rate and postoperative recurrence rates when applied the neoadjuvant chemotherapy in patients with osteosarcoma， may reduce the incidence of complications， improve the quality of life. (王蒙 孙佳冰)
[关键词] 系统护理干预；新辅助化疗；骨肉瘤；毒副作用
[中图分类号] R595.2 [文献标识码] A [文章编号] 1673-7210(2016)07(a)-0160-04
[Abstract] Objective To explore and analyze the toxic and side effect of systematic nursing intervention on neoadjuvant chemotherapy for patients with osteosarcoma. Methods Ninety patients with osteosarcoma treated with neoadjuvant chemotherapy in the First Affiliated Hospital of Harbin Medical University from January 2014 to January 2015 were selected. All the patients were divided into two groups according to a random number table， the conventional nursing care group and systemic nursing intervention group， 45 cases in each group. The postoperative survival rate， tumor recurrence rate， tumor cell necrosis rate 1 year postoperative follow-up， nursing satisfaction and life quality of patients in the two groups during the period of chemotherapy were compared. Results The survival rate， tumor recurrence rate and tumor cell death rate of patients in the two group1 year postoperative follow-up had no statistically significant difference (P > 0.05). The nausea and vomiting， oral mucositis， liver and kidney impairment， pathological fracture， hematoma， infection rate， incidence of pain of the systemic nursing intervention group were lower than those of the conventional nursing group， the differences were statistically significant (P < 0.05). The nursing satisfaction rate of the conventional nursing group was 75.56%， while the systemic nursing intervention group was 93.33%， the nursing satisfaction of the systemic nursing intervention group was obviously higher than that of the conventional nursing group， the differences were statistically significant (P < 0.05). The physical function， role function， cognitive function， emotional function and social function scores of the systemic nursing intervention group were lower than those of the conventional nursing care group， the differences were statistically significant (P < 0.05). Conclusion The systemic nursing intervention will not affect generation rate and postoperative recurrence rates when applied the neoadjuvant chemotherapy in patients with osteosarcoma， may reduce the incidence of complications， improve the quality of life. (王蒙 孙佳冰)